Literature DB >> 1130836

Prevention of Ozonide-Induced Heinz Bodies in human Erythrocytes by Vitamin E.

D B Menzel, R J Slaughter, A M Bryant, H O Jauregui.   

Abstract

Methyl oleate ozonide, a proposed intermediary in ozone intoxication, produced Heinz body inclusions in human erythrocytes at concentrations of from 10-4 to 2 x 10-3 M. Daily oral supplementation with either 100 mg or 200 mg of D-alpha-tocopheryl acetate prevented Heinz body formation by methyl oleate ozonide. These observations suggest that the protective effects of vitamin E against ozone-produced toxicants occurs in man as well as in animals.

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Year:  1975        PMID: 1130836     DOI: 10.1080/00039896.1975.10666688

Source DB:  PubMed          Journal:  Arch Environ Health        ISSN: 0003-9896


  3 in total

1.  Separation and spectral data of the six isomeric ozonides from methyl oleate.

Authors:  M Wu; D F Church; T J Mahier; S A Barker; W A Pryor
Journal:  Lipids       Date:  1992-02       Impact factor: 1.880

2.  Influence of dietary vitamin E on susceptibility to ozone exposure.

Authors:  E J Calabrese; J Victor; M A Stoddard
Journal:  Bull Environ Contam Toxicol       Date:  1985-03       Impact factor: 2.151

3.  Effect of methyl oleate ozonide, a possible ozone intermediate, on normal and G-6-PD deficient erythrocytes.

Authors:  E J Calabrese; G S Moore; P Williams
Journal:  Bull Environ Contam Toxicol       Date:  1982-10       Impact factor: 2.151

  3 in total

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