| Literature DB >> 11305362 |
S J Estill1, K Fay, J A Garcia.
Abstract
Most mixed strain progeny from gene-knockout experiments typically originate from C57BL/6J and one of the 129 substrains, frequently 129S6/SvEvTac. The results of this behavioral survey suggest that C57BL/6J:129S6/SvEvTac mixed strain mice are amenable to behavioral testing. The variability in behavioral tasks for subjects arising from this mixed strain genetic background does not preclude screening with a battery of behavioral tests. With clues provided by a screen of mixed strain subjects, follow-up analyses with isogenic, congenic, or F1 hybrid animals may be targeted to specific behavioral themes.Entities:
Mesh:
Year: 2001 PMID: 11305362 DOI: 10.1023/a:1008955016170
Source DB: PubMed Journal: Transgenic Res ISSN: 0962-8819 Impact factor: 2.788