| Literature DB >> 11304684 |
C Dal Farra1, P Sarret, V Navarro, J M Botto, J Mazella, J P Vincent.
Abstract
The expression of the 3 currently known neurotensin receptors was studied in human cancer cells of prostatic, colonic or pancreatic origin by means of RT-PCR analysis and binding experiments. All the cells selected for this work have been shown to exhibit a growth response to neurotensin. We found that the 7 transmembrane domain, levocabastine insensitive receptor (NTR1) is expressed in most but not all of the cells studied whereas the 7 transmembrane domain, levocabastine sensitive receptor (NTR2) is present in none of these cells. The 100 kDa-type I neurotensin receptor (NTR3) is expressed in all the cells assayed. Moreover, we demonstrated that neurotensin can stimulate the growth of CHO cells stably transfected with the NTR3. Taken together, our results strongly suggest that the NTR3 subtype could be involved in the growth response of human cancer cells to neurotensin.Entities:
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Year: 2001 PMID： 11304684 DOI： 10.1002/ijc.1225
Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396