W H Kutteh1, R D Franklin. 1. Division of Reproductive Endocrinology and Immunology, Department of Obstetrics and Gynecology, University of Tennessee, Memphis, 38163-2116, USA.
Abstract
OBJECTIVES: Our aims were to determine immunoglobulin and cytokine levels in cervical mucus obtained from women during each trimester of pregnancy and to compare these levels with those reported in normally menstruating women and in women taking oral contraceptives. STUDY DESIGN: Cervical mucus samples were collected at specified intervals from 36 pregnant women. An enzyme-linked immunosorbent assay was used to quantitate the presence of immunoglobulins A and G and interleukins 1 beta, 6, and 10 in cervical mucus. RESULTS: Immunoglobulin A in cervical mucus remained stable during each trimester of pregnancy (26 mg/dL). Cervical mucus immunoglobulin G decreased from a first-trimester high of 44.4 mg/dL to lower levels in the second and third trimesters. Levels of interleukin 1 beta increased significantly from the first trimester (4261 pg/mL) to 12,899 pg/mL in the second trimester (P <.01). CONCLUSION: These data suggest a possible correlation of reproductive hormones and immunologic factors in the female reproductive tract during pregnancy.
OBJECTIVES: Our aims were to determine immunoglobulin and cytokine levels in cervical mucus obtained from women during each trimester of pregnancy and to compare these levels with those reported in normally menstruating women and in women taking oral contraceptives. STUDY DESIGN: Cervical mucus samples were collected at specified intervals from 36 pregnant women. An enzyme-linked immunosorbent assay was used to quantitate the presence of immunoglobulins A and G and interleukins 1 beta, 6, and 10 in cervical mucus. RESULTS: Immunoglobulin A in cervical mucus remained stable during each trimester of pregnancy (26 mg/dL). Cervical mucus immunoglobulin G decreased from a first-trimester high of 44.4 mg/dL to lower levels in the second and third trimesters. Levels of interleukin 1 beta increased significantly from the first trimester (4261 pg/mL) to 12,899 pg/mL in the second trimester (P <.01). CONCLUSION: These data suggest a possible correlation of reproductive hormones and immunologic factors in the female reproductive tract during pregnancy.
Authors: Brenna L Hughes; Riana Dutt; Christina Raker; Melody Barthelemy; Richard M Rossoll; Bharat Ramratnam; Charles R Wira; Susan Cu-Uvin Journal: Am J Obstet Gynecol Date: 2016-07-05 Impact factor: 8.661
Authors: Jordan K Kyongo; Tania Crucitti; Joris Menten; Liselotte Hardy; Piet Cools; Johan Michiels; Sinead Delany-Moretlwe; Mary Mwaura; Gilles Ndayisaba; Sarah Joseph; Raina Fichorova; Janneke van de Wijgert; Guido Vanham; Kevin K Ariën; Vicky Jespers Journal: Clin Vaccine Immunol Date: 2015-03-11
Authors: Brenna L Anderson; Hector Mendez-Figueroa; Joshua D Dahlke; Christina Raker; Sharon L Hillier; Susan Cu-Uvin Journal: Am J Obstet Gynecol Date: 2013-01-10 Impact factor: 8.661