BACKGROUND: Disruption of the G1/S check point leads to uncontrolled cell growth, resulting in the development of cancers. MATERIALS AND METHODS: Cell cycle regulatory molecules were investigated in 33 surgically resected hepatocellular carcinoma (HCC) samples from 30 patients by Western blotting. RESULTS: Enhanced expressions of cyclin E and cyclin A were detected at frequencies of 18/33 and 26/33 in HCCs, respectively, as compared with their neighboring noncancerous tissues. The enhanced expression of cyclin E, but not that of cyclin A, correlated with hyperphosphorylation of pRb and high frequency of Ki-67-positive cells. Thus, the HCCs with enhanced cyclin E expression probably contain a relatively large number of proliferating cancer cells. CONCLUSIONS: The degree of cyclin E expression can be used as a prognostic parameter of HCC. In addition, cyclin E may become a molecular target in the treatment of HCCs.
BACKGROUND: Disruption of the G1/S check point leads to uncontrolled cell growth, resulting in the development of cancers. MATERIALS AND METHODS: Cell cycle regulatory molecules were investigated in 33 surgically resected hepatocellular carcinoma (HCC) samples from 30 patients by Western blotting. RESULTS: Enhanced expressions of cyclin E and cyclin A were detected at frequencies of 18/33 and 26/33 in HCCs, respectively, as compared with their neighboring noncancerous tissues. The enhanced expression of cyclin E, but not that of cyclin A, correlated with hyperphosphorylation of pRb and high frequency of Ki-67-positive cells. Thus, the HCCs with enhanced cyclin E expression probably contain a relatively large number of proliferating cancer cells. CONCLUSIONS: The degree of cyclin E expression can be used as a prognostic parameter of HCC. In addition, cyclin E may become a molecular target in the treatment of HCCs.
Authors: Ji Yeon Baek; Shelli M Morris; Jean Campbell; Nelson Fausto; Matthew M Yeh; William M Grady Journal: Int J Cancer Date: 2010-09-01 Impact factor: 7.396
Authors: Rakesh Dachineni; Guoqiang Ai; D Ramesh Kumar; Satya S Sadhu; Hemachand Tummala; G Jayarama Bhat Journal: Mol Cancer Res Date: 2015-12-18 Impact factor: 5.852
Authors: Khaled Aziz; Jazeel F Limzerwala; Ines Sturmlechner; Erin Hurley; Cheng Zhang; Karthik B Jeganathan; Grace Nelson; Steve Bronk; Raul O Fierro Velasco; Erik-Jan van Deursen; Daniel R O'Brien; Jean-Pierre A Kocher; Sameh A Youssef; Janine H van Ree; Alain de Bruin; Hilda van den Bos; Diana C J Spierings; Floris Foijer; Bart van de Sluis; Lewis R Roberts; Gregory J Gores; Hu Li; Jan M van Deursen Journal: Gastroenterology Date: 2019-03-13 Impact factor: 22.682