| Literature DB >> 11294390 |
K J Wilson1, C R Illig, N Subasinghe, J B Hoffman, M J Rudolph, R Soll, C J Molloy, R Bone, D Green, T Randall, M Zhang, F A Lewandowski, Z Zhou, C Sharp, D Maguire, B Grasberger, R L DesJarlais, J Spurlino.
Abstract
The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino-1,3-thiazolyl]-thiophene-2-carboxamidines is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities.Entities:
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Year: 2001 PMID： 11294390 DOI： 10.1016/s0960-894x(01)00102-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823