Literature DB >> 11293544

Fe-type nitrile hydratase.

I Endo1, M Nojiri, M Tsujimura, M Nakasako, S Nagashima, M Yohda, M Odaka.   

Abstract

The characteristic features of Fe-type nitrile hydratase (NHase) from Rhodococcus sp. N-771 are described. Through the biochemical analyses, we have found that nitric oxide (NO) regulates the photoreactivity of this enzyme by association with the non-heme iron center and photoinduced dissociation from it. The regulation is realized by a unique structure of the catalytic non-heme iron center composed of post-translationally modified cysteine-sulfinic (Cys-SO2H) and -sulfenic acids (Cys-SOH). To understand the biogenic mechanism and the functional role of these modifications, we constructed an over-expression system of whole NHase and individual subunits in Escherichia coli. The results of the studies on several recombinant NHases have shown that the Cys-SO2H oxidation of alphaC112 is indispensable for the catalytic activity of Fe-type NHase.

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Year:  2001        PMID： 11293544     DOI： 10.1016/s0162-0134(00)00171-9

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


  22 in total

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2.  Photoactive Ruthenium Nitrosyls: Effects of Light and Potential Application as NO Donors.

Authors:  Michael J Rose; Pradip K Mascharak
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3.  Sulfur versus iron oxidation in an iron-thiolate model complex.

Authors:  Aidan R McDonald; Michael R Bukowski; Erik R Farquhar; Timothy A Jackson; Kevin D Koehntop; Mi Sook Seo; Raymond F De Hont; Audria Stubna; Jason A Halfen; Eckard Münck; Wonwoo Nam; Lawrence Que
Journal:  J Am Chem Soc       Date:  2010-11-11       Impact factor: 15.419

4.  Synthesis and ligand non-innocence of thiolate-ligated (N4S) Iron(II) and nickel(II) bis(imino)pyridine complexes.

Authors:  Leland R Widger; Yunbo Jiang; Maxime A Siegler; Devesh Kumar; Reza Latifi; Sam P de Visser; Guy N L Jameson; David P Goldberg
Journal:  Inorg Chem       Date:  2013-08-30       Impact factor: 5.165

5.  Sulfur K-edge XAS and DFT calculations on P450 model complexes: effects of hydrogen bonding on electronic structure and redox potentials.

Authors:  Abhishek Dey; Taka-aki Okamura; Norikazu Ueyama; Britt Hedman; Keith O Hodgson; Edward I Solomon
Journal:  J Am Chem Soc       Date:  2005-08-31       Impact factor: 15.419

6.  Sulfur oxygenation in biomimetic non-heme iron-thiolate complexes.

Authors:  Alison C McQuilken; David P Goldberg
Journal:  Dalton Trans       Date:  2012-08-28       Impact factor: 4.390

7.  Spectroscopy of non-heme iron thiolate complexes: insight into the electronic structure of the low-spin active site of nitrile hydratase.

Authors:  Pierre Kennepohl; Frank Neese; Dirk Schweitzer; Henry L Jackson; Julie A Kovacs; Edward I Solomon
Journal:  Inorg Chem       Date:  2005-03-21       Impact factor: 5.165

8.  Properties of square-pyramidal alkyl-thiolate Fe(III) complexes, including an analogue of the unmodified form of nitrile hydratase.

Authors:  Priscilla Lugo-Mas; Wendy Taylor; Dirk Schweitzer; Roslyn M Theisen; Liang Xu; Jason Shearer; Rodney D Swartz; Morgan C Gleaves; Antonio Dipasquale; Werner Kaminsky; Julie A Kovacs
Journal:  Inorg Chem       Date:  2008-12-01       Impact factor: 5.165

9.  A nitrile hydratase in the eukaryote Monosiga brevicollis.

Authors:  Konrad U Foerstner; Tobias Doerks; Jean Muller; Jeroen Raes; Peer Bork
Journal:  PLoS One       Date:  2008-12-19       Impact factor: 3.240

10.  A subset of the diverse COG0523 family of putative metal chaperones is linked to zinc homeostasis in all kingdoms of life.

Authors:  Crysten E Haas; Dmitry A Rodionov; Janette Kropat; Davin Malasarn; Sabeeha S Merchant; Valérie de Crécy-Lagard
Journal:  BMC Genomics       Date:  2009-10-12       Impact factor: 3.969
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