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Literature DB >> 1129140

A model for chromatin sub-structure incorporating symmetry considerations of histone oligomers.

Abstract

Symmetry considerations of the kind of structures which can be generated when dimers of histones f2al-f3 and f2a2-f2b interact lead to the following conclusions: chromatin subunits based on closed-shell structures give rise to discrete, non-interacting nucleoprotein subunits with the histones arranged at random along the DNA chain; open structures based on infinite helices give rise to highly ordered, regular arrangements of dimers. A model is proposed in which helical polymers of f2al-f3 and f2b-f2a2 form a central core with the DNA helically arranged around it. The helical repeat contains 9.6 turns of B-form DNA and one molecule each of f2al, f2a2, f2b, f3 and f1. The pitch of the helix is 53Angstrom and the other diameter 130Angstrom. The protein molecular repeat is 106Angstrom.

Entities: Chemical

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Year: 1975 PMID： 1129140 PMCID： PMC342846 DOI： 10.1093/nar/2.3.405

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

31 in total

1. A model for particulate structure in chromatin.

Authors: K E Van Holde; C G Sahasrabuddhe; B R Shaw
Journal: Nucleic Acids Res Date: 1974-11 Impact factor: 16.971

2. A new procedure for the isolation and fractionation of histones.

Authors: D R. van der Westhuyzen; C von Holt
Journal: FEBS Lett Date: 1971-05-20 Impact factor: 4.124

3. Covalent cross-linking of histones in chromatin.

Authors: J E Hyde; I O Walker
Journal: FEBS Lett Date: 1975-02-01 Impact factor: 4.124

4. Conformations and interactions of histones and their role in chromosome structure.

Authors: E M Bradbury; P D Cary; C Crane-Robinson; H W Rattle
Journal: Ann N Y Acad Sci Date: 1973-12-31 Impact factor: 5.691

5. Interactions of histone LAK (f2a2) with histones KAS (f2b) and GRK (f2a1).

Authors: J A D'Anna; I Isenberg
Journal: Biochemistry Date: 1974-05-07 Impact factor: 3.162

6. A two-subunit histone complex from calf thymus.

Authors: D E Roark; T E Geoghegan; G H Keller
Journal: Biochem Biophys Res Commun Date: 1974-07-24 Impact factor: 3.575

7. On the structure of nucleohistone.

Authors: S Bram; H Ris
Journal: J Mol Biol Date: 1971-02-14 Impact factor: 5.469

8. A study of calf thymus histone fraction F2(b) by gel filtration.

Authors: P A Edwards; K V Shooter
Journal: Biochem J Date: 1970-11 Impact factor: 3.857

Review 9. Histones: structure and function.

Authors: R J DeLange; E L Smith
Journal: Annu Rev Biochem Date: 1971 Impact factor: 23.643

3. Chromatin structure: a property of the higher structures of chromatin and in the time course of its formation during chromatin replication.

Authors: L A Burgoyne; J D Mobbs; A J Marshall
Journal: Nucleic Acids Res Date: 1976-12 Impact factor: 16.971

A model for chromatin sub-structure incorporating symmetry considerations of histone oligomers.

1. A model for particulate structure in chromatin.

2. A new procedure for the isolation and fractionation of histones.

3. Covalent cross-linking of histones in chromatin.

4. Conformations and interactions of histones and their role in chromosome structure.

5. Interactions of histone LAK (f2a2) with histones KAS (f2b) and GRK (f2a1).

6. A two-subunit histone complex from calf thymus.

7. On the structure of nucleohistone.

8. A study of calf thymus histone fraction F2(b) by gel filtration.

Review 9. Histones: structure and function.

10. The reactivity of the thiol groups of calf thymus deoxyribonucleohistone.

1. An approach to histone nearest neighbours in extended chromatin.

2. Model studies of chromatin structure based on X-ray diffraction data.

3. Chromatin structure: a property of the higher structures of chromatin and in the time course of its formation during chromatin replication.

4. Transcription of the nonrepeated fraction of "accessible" DNA in rat liver chromatin.

5. Chemical evidence that chromatin DNA exists as 160 base pair beads interspersed with 40 base pair bridges.

6. Studies on chromatin. V. A model for the structure of chromatin subunit.

Review 7. Steroid hormone receptors in the regulation of differentiation. A review.

8. Histone dimers: a fundamental unit in histone assembly.

9. Low resolution models of self-assembled histone fibers from X-ray diffraction studies.

10. The helical model of the nucleosome core.