OBJECTIVE: To assess the chromosomal aberrations in the abortus in recurrent miscarriage and the live birth rate after a euploid or aneuploid miscarriage. DESIGN: Retrospective analysis. SETTING: Tertiary referral unit in university hospital. PATIENT(S): One hundred sixty-seven patients with 3 to 16 miscarriages before 20 weeks. INTERVENTION(S): Material collected at curettage from 167 abortuses was analyzed by standard G-banding techniques. MAIN OUTCOME MEASURE(S): The incidence of aberrations and the outcome of the subsequent pregnancy were assessed according to the embryonic karyotype. RESULT(S): In this study 125 specimens were successfully karyotyped. Of these, 29% (36 of 125) had chromosome aberrations; 94% of the aberrations were aneuploidy, and 6% were structural. The most prevalent anomalies were chromosome 16, 18, and 21 trisomies, triploidy, and monosomy X. After an aneuploid miscarriage, there was a 68% subsequent live birth rate (13 of 19) compared to the 41% (16 of 39) rate after a euploid abortion. CONCLUSION(S): The low (29%) incidence of aberrations indicates that alternative mechanisms may be responsible for the majority of recurrent miscarriages. These figures provide a basis for assessing the efficacy of therapy for recurrent miscarriage. If further studies confirm that patients with karyotypically abnormal fetuses have a good prognosis, an informed decision can be made as to whether further investigations and treatment should be undertaken.
OBJECTIVE: To assess the chromosomal aberrations in the abortus in recurrent miscarriage and the live birth rate after a euploid or aneuploid miscarriage. DESIGN: Retrospective analysis. SETTING: Tertiary referral unit in university hospital. PATIENT(S): One hundred sixty-seven patients with 3 to 16 miscarriages before 20 weeks. INTERVENTION(S): Material collected at curettage from 167 abortuses was analyzed by standard G-banding techniques. MAIN OUTCOME MEASURE(S): The incidence of aberrations and the outcome of the subsequent pregnancy were assessed according to the embryonic karyotype. RESULT(S): In this study 125 specimens were successfully karyotyped. Of these, 29% (36 of 125) had chromosome aberrations; 94% of the aberrations were aneuploidy, and 6% were structural. The most prevalent anomalies were chromosome 16, 18, and 21 trisomies, triploidy, and monosomy X. After an aneuploid miscarriage, there was a 68% subsequent live birth rate (13 of 19) compared to the 41% (16 of 39) rate after a euploid abortion. CONCLUSION(S): The low (29%) incidence of aberrations indicates that alternative mechanisms may be responsible for the majority of recurrent miscarriages. These figures provide a basis for assessing the efficacy of therapy for recurrent miscarriage. If further studies confirm that patients with karyotypically abnormal fetuses have a good prognosis, an informed decision can be made as to whether further investigations and treatment should be undertaken.
Authors: Mohamed M Farghali; Abdel-Latif G El-Kholy; Khaled H Swidan; Ibrahim A Abdelazim; Ahmed R Rashed; Ezzat El-Sobky; Mostafa F Goma Journal: J Turk Ger Gynecol Assoc Date: 2015-11-02
Authors: T V Nikitina; E A Sazhenova; D I Zhigalina; E N Tolmacheva; N N Sukhanova; I N Lebedev Journal: J Assist Reprod Genet Date: 2020-02-03 Impact factor: 3.412
Authors: Mercy Y Laurino; Robin L Bennett; Devki S Saraiya; Lisa Baumeister; Debra Lochner Doyle; Kathleen Leppig; Barbara Pettersen; Robert Resta; Larry Shields; Stefanie Uhrich; Elizabeth A Varga; Wendy H Raskind Journal: J Genet Couns Date: 2005-06 Impact factor: 2.537