| Literature DB >> 11286686 |
C D Tsoukas1, J A Grasis, K A Ching, Y Kawakami, T Kawakami.
Abstract
Itk/Emt, a tec family tyrosine kinase, is important for T-cell development and activation through the antigen receptor. Here, we review data suggesting that Itk/Emt is involved in the generation of critical second messengers (Ca(2+), PKC) whose duration it modulates by regulation of cytoskeletal reorganization. We propose that Itk/Emt constitutes an important link between these critical signaling events.Entities:
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Year: 2001 PMID： 11286686 DOI： 10.1016/s1471-4906(00)01795-6
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687