Literature DB >> 19541372

Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders.

Dawn Eggert1, Prasanta K Dash, Nawal Serradji, Chang-Zhi Dong, Pascal Clayette, Francoise Heymans, Huanyu Dou, Santhi Gorantla, Harris A Gelbard, Larisa Poluektova, Howard E Gendelman.   

Abstract

The neuroregulatory activities of PMS-601, a platelet activating factor antagonist, were investigated in laboratory and animal models of HIV-1 encephalitis (HIVE). For the former, PMS-601 reduced monocyte-derived macrophage pro-inflammatory secretions, multinucleated giant cell (MGC) formation, and neuronal loss independent of antiretroviral responses. PMS-601 treatment of HIVE severe combined immunodeficient mice showed reduced microgliosis, MGCs and neurodegeneration. These observations support the further development of PMS-601 as an adjunctive therapy for HIV-1 associated neurocognitive disorders.

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Year:  2009        PMID： 19541372      PMCID： PMC2757154          DOI： 10.1016/j.jneuroim.2009.06.002

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  102 in total

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  17 in total

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3.  Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders.

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Review 7.  The Role of Platelet-Activating Factor in Chronic Inflammation, Immune Activation, and Comorbidities Associated with HIV Infection.

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Review 8.  CNS inflammation and macrophage/microglial biology associated with HIV-1 infection.

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