BACKGROUND: It has been suggested that there is frontal lobe involvement in schizophrenia, and that it may be lateralised and gender-specific. AIMS: To clarify the structure of the frontal lobes in schizophrenia in a post-mortem series. METHOD: The volume of white matter and cortical components of the frontal lobes was measured in brains of controls and patients with schizophrenia using planimetry and the Cavalieri principle. The components measured were: superior frontal gyrus, middle frontal gyrus, a composite of inferior frontal gyrus and orbito-frontal cortex, as well as total frontal lobe cortex and white matter. In addition, the anterior cingulate gyrus was measured. RESULTS: No diagnosis, gender, diagnosis x side, diagnosis x gender or diagnosis x gender x side interactions were observed in the volume of any of the components, the grey matter as a whole or the white matter. No evidence for volumetric inter-group differences was found for the anterior cingulate gyrus. CONCLUSIONS: Such structural abnormalities as are present in the frontal lobes are more subtle than straightforward alterations in tissue volume; they may include changes in shape and the pattern of gyral folding.
BACKGROUND: It has been suggested that there is frontal lobe involvement in schizophrenia, and that it may be lateralised and gender-specific. AIMS: To clarify the structure of the frontal lobes in schizophrenia in a post-mortem series. METHOD: The volume of white matter and cortical components of the frontal lobes was measured in brains of controls and patients with schizophrenia using planimetry and the Cavalieri principle. The components measured were: superior frontal gyrus, middle frontal gyrus, a composite of inferior frontal gyrus and orbito-frontal cortex, as well as total frontal lobe cortex and white matter. In addition, the anterior cingulate gyrus was measured. RESULTS: No diagnosis, gender, diagnosis x side, diagnosis x gender or diagnosis x gender x side interactions were observed in the volume of any of the components, the grey matter as a whole or the white matter. No evidence for volumetric inter-group differences was found for the anterior cingulate gyrus. CONCLUSIONS: Such structural abnormalities as are present in the frontal lobes are more subtle than straightforward alterations in tissue volume; they may include changes in shape and the pattern of gyral folding.
Authors: Marek Kubicki; Carl-Fredrik Westin; Stephan E Maier; Melissa Frumin; Paul G Nestor; Dean F Salisbury; Ron Kikinis; Ferenc A Jolesz; Robert W McCarley; Martha E Shenton Journal: Am J Psychiatry Date: 2002-05 Impact factor: 18.112
Authors: Matthew Roy Williams; Thomas Hampton; Ronald K B Pearce; Steven Richard Hirsch; Olaf Ansorge; Maria Thom; Michael Maier Journal: Eur Arch Psychiatry Clin Neurosci Date: 2012-06-04 Impact factor: 5.270
Authors: M R Williams; R Chaudhry; S Perera; R K B Pearce; S R Hirsch; O Ansorge; M Thom; M Maier Journal: Eur Arch Psychiatry Clin Neurosci Date: 2012-05-19 Impact factor: 5.270
Authors: Paul G Nestor; Marek Kubicki; Ronald J Gurrera; Margaret Niznikiewicz; Melissa Frumin; Robert W McCarley; Martha E Shenton Journal: Neuropsychology Date: 2004-10 Impact factor: 3.295
Authors: Lynn D Selemon; Lei Wang; Mary Beth Nebel; John G Csernansky; Patricia S Goldman-Rakic; Pasko Rakic Journal: Biol Psychiatry Date: 2005-01-01 Impact factor: 13.382
Authors: Fabrizio Pizzagalli; Guillaume Auzias; Qifan Yang; Samuel R Mathias; Joshua Faskowitz; Joshua D Boyd; Armand Amini; Denis Rivière; Katie L McMahon; Greig I de Zubicaray; Nicholas G Martin; Jean-François Mangin; David C Glahn; John Blangero; Margaret J Wright; Paul M Thompson; Peter Kochunov; Neda Jahanshad Journal: Commun Biol Date: 2020-09-15