Literature DB >> 11282337

Dehydrogenases and transaminases in asymmetric synthesis.

J D Stewart1.   

Abstract

Improved stereoselectivity in dehydrogenase-mediated reductions has been achieved by rationally designed gene overexpression and knockouts in Saccharomyces cerevisiae cells and by isolating and characterizing novel dehydrogenases from other organisms. Transaminases have been used to prepare unnatural amines and amino acids in good yields, particularly when the equilibria are shifted by selective product removal.

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Year:  2001        PMID： 11282337     DOI： 10.1016/s1367-5931(00)00180-0

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  18 in total

Review 1.  Enzymatic synthesis of chiral intermediates for pharmaceuticals.

Authors:  Ramesh Patel; Ronald Hanson; Animesh Goswami; Venkata Nanduri; Amit Banerjee; Mary-Jo Donovan; Steven Goldberg; Robert Johnston; David Brzozowski; Thomas Tully; Jeffrey Howell; Dana Cazzulino; Rapheal Ko
Journal:  J Ind Microbiol Biotechnol       Date:  2003-03-25       Impact factor: 3.346

2.  Cloning and characterization of a novel beta-transaminase from Mesorhizobium sp. strain LUK: a new biocatalyst for the synthesis of enantiomerically pure beta-amino acids.

Authors:  Juhan Kim; Dohyun Kyung; Hyungdon Yun; Byung-Kwan Cho; Joo-Hyun Seo; Minho Cha; Byung-Gee Kim
Journal:  Appl Environ Microbiol       Date:  2007-01-26       Impact factor: 4.792

3.  Crystal structure of the aromatic-amino-acid aminotransferase from Streptococcus mutans.

Authors:  Xuzhen Cong; Xiaolu Li; Shentao Li
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2019-01-24       Impact factor: 1.056

4.  A novel meso-Diaminopimelate dehydrogenase from Symbiobacterium thermophilum: overexpression, characterization, and potential for D-amino acid synthesis.

Authors:  Xiuzhen Gao; Xi Chen; Weidong Liu; Jinhui Feng; Qiaqing Wu; Ling Hua; Dunming Zhu
Journal:  Appl Environ Microbiol       Date:  2012-09-28       Impact factor: 4.792

5.  DNA-catalyzed reductive amination.

Authors:  On Yi Wong; Amanda E Mulcrone; Scott K Silverman
Journal:  Angew Chem Int Ed Engl       Date:  2011-10-12       Impact factor: 15.336

6.  Development of dynamic kinetic resolution on large scale for (±)-1-phenylethylamine.

Authors:  Lisa K Thalén; Jan-E Bäckvall
Journal:  Beilstein J Org Chem       Date:  2010-09-13       Impact factor: 2.883

7.  Active-Site Engineering of ω-Transaminase for Production of Unnatural Amino Acids Carrying a Side Chain Bulkier than an Ethyl Substituent.

Authors:  Sang-Woo Han; Eul-Soo Park; Joo-Young Dong; Jong-Shik Shin
Journal:  Appl Environ Microbiol       Date:  2015-07-31       Impact factor: 4.792

8.  omega-Amino acid:pyruvate transaminase from Alcaligenes denitrificans Y2k-2: a new catalyst for kinetic resolution of beta-amino acids and amines.

Authors:  Hyungdon Yun; Seongyop Lim; Byung-Kwan Cho; Byung-Gee Kim
Journal:  Appl Environ Microbiol       Date:  2004-04       Impact factor: 4.792

9.  Metabolomics analysis identifies d-Alanine-d-Alanine ligase as the primary lethal target of d-Cycloserine in mycobacteria.

Authors:  Steven Halouska; Robert J Fenton; Denise K Zinniel; Darrell D Marshall; Raúl G Barletta; Robert Powers
Journal:  J Proteome Res       Date:  2013-12-13       Impact factor: 4.466

10.  Biochemical properties and crystal structure of a β-phenylalanine aminotransferase from Variovorax paradoxus.

Authors:  Ciprian G Crismaru; Gjalt G Wybenga; Wiktor Szymanski; Hein J Wijma; Bian Wu; Sebastian Bartsch; Stefaan de Wildeman; Gerrit J Poelarends; Ben L Feringa; Bauke W Dijkstra; Dick B Janssen
Journal:  Appl Environ Microbiol       Date:  2012-10-19       Impact factor: 4.792
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