Literature DB >> 11281841

Targeting double stranded DNA with peptide nucleic acid (PNA).

P E Nielsen1.   

Abstract

PNA (peptide nucleic acid) is a DNA mimic with a pseudopeptide (polyamide) backbone which can be used to target double stranded DNA with high sequence specificity. PNA therefore has great potential in the development of biomolecular tools for manipulation of DNA as well as for the development of DNA targeted gene therapeutic drugs. The status of this field is discussed in terms of PNA binding modes and mechanism as well as applications.

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Year:  2001        PMID： 11281841     DOI： 10.2174/0929867003373373

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  23 in total

Review 1.  Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities.

Authors:  Taco G Uil; Hidde J Haisma; Marianne G Rots
Journal:  Nucleic Acids Res       Date:  2003-11-01       Impact factor: 16.971

2.  Unique properties of purine/pyrimidine asymmetric PNA.DNA duplexes: differential stabilization of PNA.DNA duplexes by purines in the PNA strand.

Authors:  Anjana Sen; Peter E Nielsen
Journal:  Biophys J       Date:  2005-12-02       Impact factor: 4.033

3.  Padlock oligonucleotides as a tool for labeling superhelical DNA.

Authors:  Thibaut Roulon; Dominique Coulaud; Etienne Delain; Eric Le Cam; Claude Hélène; Christophe Escudé
Journal:  Nucleic Acids Res       Date:  2002-02-01       Impact factor: 16.971

4.  Radiolabeled oligonucleotides for antisense imaging.

Authors:  Arun K Iyer; Jiang He
Journal:  Curr Org Synth       Date:  2011-08-01       Impact factor: 1.975

5.  Delivery of Peptide Nucleic Acids Using an Argininocalix[4]arene as Vector.

Authors:  Alessia Finotti; Jessica Gasparello; Alessandro Casnati; Roberto Corradini; Roberto Gambari; Francesco Sansone
Journal:  Methods Mol Biol       Date:  2021

6.  Orientation preferences of backbone secondary amide functional groups in peptide nucleic acid complexes: quantum chemical calculations reveal an intrinsic preference of cationic D-amino acid-based chiral PNA analogues for the P-form.

Authors:  Christopher M Topham; Jeremy C Smith
Journal:  Biophys J       Date:  2006-10-27       Impact factor: 4.033

7.  Localization and dynamics of small circular DNA in live mammalian nuclei.

Authors:  Giulia Mearini; Peter E Nielsen; Frank O Fackelmayer
Journal:  Nucleic Acids Res       Date:  2004-05-11       Impact factor: 16.971

8.  Detection of a rare oligo(A) repeat tract mutation (8As-->7As) in the sequence encoding the La/SS-B autoantigen.

Authors:  Imre Semsei; Shannon Maier; Jennifer Workman-Azbill; László Urbán; Kathy Moser; Margit Zeher; Michael Bachmann; A Darise Farris
Journal:  Anal Biochem       Date:  2007-07-05       Impact factor: 3.365

9.  Uptake by human glioma cell lines and biological effects of a peptide-nucleic acids targeting miR-221.

Authors:  Eleonora Brognara; Enrica Fabbri; Elena Bazzoli; Giulia Montagner; Claudio Ghimenton; Albino Eccher; Cinzia Cantù; Alex Manicardi; Nicoletta Bianchi; Alessia Finotti; Giulia Breveglieri; Monica Borgatti; Roberto Corradini; Valentino Bezzerri; Giulio Cabrini; Roberto Gambari
Journal:  J Neurooncol       Date:  2014-03-05       Impact factor: 4.130

10.  Improved synthesis strategy for peptide nucleic acids (PNA) appropriate for cell-specific fluorescence imaging.

Authors:  Rüdiger Pipkorn; Manfred Wiessler; Waldemar Waldeck; Ute Hennrich; Kiyoshi Nokihara; Marcel Beining; Klaus Braun
Journal:  Int J Med Sci       Date:  2011-11-05       Impact factor: 3.738
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