Literature DB >> 11279157

p300-mediated acetylation of human transcriptional coactivator PC4 is inhibited by phosphorylation.

B R Kumar1, V Swaminathan, S Banerjee, T K Kundu.   

Abstract

The human positive coactivator 4 (PC4) acts as a general coactivator for activator-dependent transcription, the activity of which is regulated negatively by phosphorylation. We report here that PC4 can be acetylated specifically by another coactivator, p300. Interestingly, phosphorylation of PC4 by casein kinase II inhibits the p300-mediated acetylation. Mass spectral analysis revealed that there are at least two lysine residues acetylated in PC4, as a result of which its DNA binding activity is stimulated.

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Year:  2001        PMID： 11279157     DOI： 10.1074/jbc.M100934200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  14 in total

1.  Acetylation of core histones in response to HDAC inhibitors is diminished in mitotic HeLa cells.

Authors:  Jason S Patzlaff; Edith Terrenoire; Bryan M Turner; William C Earnshaw; James R Paulson
Journal:  Exp Cell Res       Date:  2010-05-07       Impact factor: 3.905

2.  General transcriptional coactivator PC4 activates p53 function.

Authors:  Sourav Banerjee; B R Prashanth Kumar; Tapas K Kundu
Journal:  Mol Cell Biol       Date:  2004-03       Impact factor: 4.272

3.  Transcriptional coactivator PC4, a chromatin-associated protein, induces chromatin condensation.

Authors:  Chandrima Das; Kohji Hizume; Kiran Batta; B R Prashanth Kumar; Shrikanth S Gadad; Semanti Ganguly; Stephanie Lorain; Alain Verreault; Parag P Sadhale; Kunio Takeyasu; Tapas K Kundu
Journal:  Mol Cell Biol       Date:  2006-09-18       Impact factor: 4.272

4.  Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription.

Authors:  Arounie Tavenet; Audrey Suleau; Géraldine Dubreuil; Roberto Ferrari; Cécile Ducrot; Magali Michaut; Jean-Christophe Aude; Giorgio Dieci; Olivier Lefebvre; Christine Conesa; Joël Acker
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-11       Impact factor: 11.205

5.  Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications.

Authors:  Kiran Batta; Tapas K Kundu
Journal:  Mol Cell Biol       Date:  2007-09-04       Impact factor: 4.272

6.  Coactivator function of positive cofactor 4 (PC4) in Sp1-directed luteinizing hormone receptor (LHR) gene transcription.

Authors:  Mingjuan Liao; Ying Zhang; Jung-Hoon Kang; Maria L Dufau
Journal:  J Biol Chem       Date:  2010-12-30       Impact factor: 5.157

7.  Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.

Authors:  Lawryn H Kasper; Tomofusa Fukuyama; Michelle A Biesen; Fayçal Boussouar; Caili Tong; Antoine de Pauw; Peter J Murray; Jan M A van Deursen; Paul K Brindle
Journal:  Mol Cell Biol       Date:  2006-02       Impact factor: 4.272

8.  Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription.

Authors:  V Swaminathan; A Hari Kishore; K K Febitha; Tapas K Kundu
Journal:  Mol Cell Biol       Date:  2005-09       Impact factor: 4.272

9.  Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu.

Authors:  Apollina Goel; Ralf Janknecht
Journal:  Mol Cell Biol       Date:  2003-09       Impact factor: 4.272

10.  The interaction between thymine DNA glycosylase and nuclear receptor coactivator 3 is required for the transcriptional activation of nuclear hormone receptors.

Authors:  Shirley Chiang; Tanya Burch; Gary Van Domselaar; Kevin Dick; Alina Radziwon; Craig Brusnyk; Megan Rae Edwards; Jessica Piper; Todd Cutts; Jingxin Cao; Xuguang Li; Runtao He
Journal:  Mol Cell Biochem       Date:  2009-08-04       Impact factor: 3.396
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