Literature DB >> 11277781

Acylation of indole under Friedel-Crafts conditions-an improved method to obtain 3-acylindoles regioselectively.

O Ottoni1, A V Neder, A K Dias, R P Cruz, L B Aquino.   

Abstract

[reaction: see text]. The reaction of unsubstituted indole with different acylating agents such as acid chlorides, anhydrides, nitriles, and amino acid derivatives in the presence of Lewis acid is reported.

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Year:  2001        PMID： 11277781

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Insecticidal activity of indole derivatives against Plutella xylostella and selectivity to four non-target organisms.

Authors:  Ângela C F Costa; Sócrates C H Cavalcanti; Alisson S Santana; Ana P S Lima; Thaysnara B Brito; Rafael R B Oliveira; Nathália A Macêdo; Paulo F Cristaldo; Ana Paula A Araújo; Leandro Bacci
Journal:  Ecotoxicology       Date:  2019-08-16       Impact factor: 2.823

2.  Acylation of N-p-Toluenesulfonylpyrrole Under Friedel-Crafts Conditions. Evidence for Organoaluminum Intermediates.

Authors:  John W Huffman; Valerie J Smith; Lea W Padgett
Journal:  Tetrahedron       Date:  2008-02-25       Impact factor: 2.457

3.  2,30-Bis(10H-indole) heterocycles: New p53/MDM2/MDMX antagonists.

Authors:  Constantinos G Neochoritis; Kan Wang; Natalia Estrada-Ortiz; Eberhardt Herdtweck; Katarzyna Kubica; Aleksandra Twarda; Krzysztof M Zak; Tad A Holak; Alexander Dömling
Journal:  Bioorg Med Chem Lett       Date:  2015-12-15       Impact factor: 2.823

4.  Late-Stage Functionalisation of Polycyclic (N-Hetero-) Aromatic Hydrocarbons by Detoxifying CYP5035S7 Monooxygenase of the White-Rot Fungus Polyporus arcularius.

Authors:  Nico D Fessner; Christopher Grimm; Wolfgang Kroutil; Anton Glieder
Journal:  Biomolecules       Date:  2021-11-17

5.  A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products.

Authors:  Vignesh Palani; Melecio A Perea; Kristen E Gardner; Richmond Sarpong
Journal:  Chem Sci       Date:  2020-11-27       Impact factor: 9.825

6.  Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.

Authors:  Nikolaos Eleftheriadis; Constantinos G Neochoritis; Niek G J Leus; Petra E van der Wouden; Alexander Dömling; Frank J Dekker
Journal:  J Med Chem       Date:  2015-09-16       Impact factor: 7.446
  6 in total

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