Literature DB >> 11274319

How do AD patients and their caregivers decide whether to enroll in a clinical trial?

J H Karlawish1, D Casarett, J Klocinski, P Sankar.   

Abstract

To examine how patients and caregivers decide whether to enroll in a clinical trial, the authors conducted semi-structured interviews with 22 family caregivers of patients with mild to moderate AD who were recruited for a clinical trial. They found that a caregiver who enrolls a patient in research generally involves the patient in the decision-making process, reports that the patient shares in the decision, and regards the risks and benefits to the patient and to the caregiver as interdependent.

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Year:  2001        PMID: 11274319     DOI: 10.1212/wnl.56.6.789

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  24 in total

1.  How redesigning AD clinical trials might increase study partners' willingness to participate.

Authors:  Jason Karlawish; Mark S Cary; Jonathan Rubright; Tom Tenhave
Journal:  Neurology       Date:  2008-12-02       Impact factor: 9.910

2.  Patient and Caregiver Assessment of the Benefits From the Clinical Use of Amyloid PET Imaging.

Authors:  Rafid Mustafa; Jared R Brosch; Gil D Rabinovici; Bradford C Dickerson; Maria C Carrillo; Bradley S Glazier; Sujuan Gao; Martha Tierney; Keith N Fargo; Mary G Austrom; Susan De Santi; David G Clark; Liana G Apostolova
Journal:  Alzheimer Dis Assoc Disord       Date:  2018 Jan-Mar       Impact factor: 2.703

3.  Differences in medication use in the Alzheimer's disease neuroimaging initiative: analysis of baseline characteristics.

Authors:  Noam U Epstein; Andrew J Saykin; Shannon L Risacher; Sujuan Gao; Martin R Farlow
Journal:  Drugs Aging       Date:  2010-08-01       Impact factor: 3.923

4.  Study partners perform essential tasks in dementia research and can experience burdens and benefits in this role.

Authors:  Betty S Black; Holly A Taylor; Peter V Rabins; Jason Karlawish
Journal:  Dementia (London)       Date:  2016-05-13

Review 5.  Facilitating Alzheimer disease research recruitment.

Authors:  Joshua D Grill; James E Galvin
Journal:  Alzheimer Dis Assoc Disord       Date:  2014 Jan-Mar       Impact factor: 2.703

6.  Why are spousal caregivers more prevalent than nonspousal caregivers as study partners in AD dementia clinical trials?

Authors:  Mark S Cary; Jonathan D Rubright; Joshua D Grill; Jason Karlawish
Journal:  Alzheimer Dis Assoc Disord       Date:  2015 Jan-Mar       Impact factor: 2.703

7.  "Thinking about it for somebody else": Alzheimer's disease research and proxy decision makers' translation of ethical principles into practice.

Authors:  Laura B Dunn; Stephanie Reyes Fisher; Melinda Hantke; Paul S Appelbaum; Daniel Dohan; Jenifer P Young; Laura Weiss Roberts
Journal:  Am J Geriatr Psychiatry       Date:  2013-02-06       Impact factor: 4.105

8.  Decision making for participation in dementia research.

Authors:  Betty S Black; Malory Wechsler; Linda Fogarty
Journal:  Am J Geriatr Psychiatry       Date:  2013-02-06       Impact factor: 4.105

9.  Capacity to consent to biomedical research's evaluation among older cognitively impaired patients. A study to validate the University of California Brief Assessment of Capacity to Consent questionnaire in French among older cognitively impaired patients.

Authors:  E Duron; M Boulay; J S Vidal; J El Bchiri; M L Fraisse; A S Rigaud; L Hugonot-Diener
Journal:  J Nutr Health Aging       Date:  2013-04       Impact factor: 4.075

10.  Researchers' perspectives on the role of study partners in dementia research.

Authors:  Betty S Black; Holly Taylor; Peter V Rabins; Jason Karlawish
Journal:  Int Psychogeriatr       Date:  2014-07-03       Impact factor: 3.878

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