Literature DB >> 11269496

The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint?

P Jares1, A Donaldson, J J Blow.   

Abstract

Cdc7/Dbf4 is a protein kinase that is required for the initiation of DNA replication in eukaryotes. Recent work has provided new clues to the role that Cdc7/Dbf4 plays in this process. A range of other observations suggest that Cdc7/Dbf4 also plays another, less well characterized, role in checkpoint function and in the maintenance of genomic integrity. In this review we attempt to bring together new information to explain how Cdc7/Dbf4 may perform these two distinct functions.

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Year:  2000        PMID： 11269496      PMCID： PMC1083750          DOI： 10.1093/embo-reports/kvd076

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  39 in total

1.  Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase.

Authors:  L Zou; B Stillman
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

2.  Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha.

Authors:  J Walter; J Newport
Journal:  Mol Cell       Date:  2000-04       Impact factor: 17.970

3.  Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity.

Authors:  H A Snaith; G W Brown; S L Forsburg
Journal:  Mol Cell Biol       Date:  2000-11       Impact factor: 4.272

4.  Hierarchy of S-phase-promoting factors: yeast Dbf4-Cdc7 kinase requires prior S-phase cyclin-dependent kinase activation.

Authors:  R Nougarède; F Della Seta; P Zarzov; E Schwob
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272

5.  Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading.

Authors:  P Jares; J J Blow
Journal:  Genes Dev       Date:  2000-06-15       Impact factor: 11.361

6.  Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.

Authors:  A Pellicioli; C Lucca; G Liberi; F Marini; M Lopes; P Plevani; A Romano; P P Di Fiore; M Foiani
Journal:  EMBO J       Date:  1999-11-15       Impact factor: 11.598

7.  Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.

Authors:  H Masai; E Matsui; Z You; Y Ishimi; K Tamai; K Arai
Journal:  J Biol Chem       Date:  2000-09-15       Impact factor: 5.157

8.  Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication.

Authors:  W Jiang; D McDonald; T J Hope; T Hunter
Journal:  EMBO J       Date:  1999-10-15       Impact factor: 11.598

9.  Premature structural changes at replication origins in a yeast minichromosome maintenance (MCM) mutant.

Authors:  D S Geraghty; M Ding; N H Heintz; D S Pederson
Journal:  J Biol Chem       Date:  2000-06-16       Impact factor: 5.157

10.  Cdc7p-Dbf4p becomes famous in the cell cycle.

Authors:  R A Sclafani
Journal:  J Cell Sci       Date:  2000-06       Impact factor: 5.285
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  36 in total

1.  Drf1, a novel regulatory subunit for human Cdc7 kinase.

Authors:  A Montagnoli; R Bosotti; F Villa; M Rialland; D Brotherton; C Mercurio; J Berthelsen; C Santocanale
Journal:  EMBO J       Date:  2002-06-17       Impact factor: 11.598

Review 2.  Multiple roles for kinases in DNA replication.

Authors:  Ghislaine Henneke; Stéphane Koundrioukoff; Ulrich Hübscher
Journal:  EMBO Rep       Date:  2003-03       Impact factor: 8.807

Review 3.  Eukaryotic MCM proteins: beyond replication initiation.

Authors:  Susan L Forsburg
Journal:  Microbiol Mol Biol Rev       Date:  2004-03       Impact factor: 11.056

4.  Cell division cycle 7 is a novel regulator of transforming growth factor-β-induced smooth muscle cell differentiation.

Authors:  Ning Shi; Wei-Bing Xie; Shi-You Chen
Journal:  J Biol Chem       Date:  2012-01-05       Impact factor: 5.157

5.  Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.

Authors:  Ying-Chou Chen; Michael Weinreich
Journal:  J Biol Chem       Date:  2010-10-29       Impact factor: 5.157

6.  Cdc7-Dbf4 and the human S checkpoint response to UVC.

Authors:  Timothy P Heffernan; Keziban Unsal-Kaçmaz; Alexandra N Heinloth; Dennis A Simpson; Richard S Paules; Aziz Sancar; Marila Cordeiro-Stone; William K Kaufmann
Journal:  J Biol Chem       Date:  2007-02-02       Impact factor: 5.157

7.  Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.

Authors:  Yi-Jun Sheu; Bruce Stillman
Journal:  Mol Cell       Date:  2006-10-06       Impact factor: 17.970

8.  Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae.

Authors:  Andrei Chabes; Bruce Stillman
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-16       Impact factor: 11.205

9.  A Dbf4 mutant contributes to bypassing the Rad53-mediated block of origins of replication in response to genotoxic stress.

Authors:  Alba Duch; Gloria Palou; Zophonias O Jonsson; Roger Palou; Enrique Calvo; James Wohlschlegel; David G Quintana
Journal:  J Biol Chem       Date:  2010-11-23       Impact factor: 5.157

10.  A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.

Authors:  Angela E Varrin; Ajai A Prasad; Rolf-Peter Scholz; Matthew D Ramer; Bernard P Duncker
Journal:  Mol Cell Biol       Date:  2005-09       Impact factor: 4.272
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