Literature DB >> 11266175

Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.

P Brown1, D S Eggleston, R C Haltiwanger, R L Jarvest, L Mensah, P J O'Hanlon, A J Pope.   

Abstract

Novel inhibitors of bacterial tyrosyl tRNA synthetase have been synthesised in which the cyclic hydroxylamine moiety of SB-219383 is replaced by C-pyranosyl derivatives. Potent and selective inhibition of bacterial tyrosyl tRNA synthetase was obtained.

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Year:  2001        PMID： 11266175     DOI： 10.1016/s0960-894x(01)00039-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

Review 1.  Structure-based discovery of antibacterial drugs.

Authors:  Katie J Simmons; Ian Chopra; Colin W G Fishwick
Journal:  Nat Rev Microbiol       Date:  2010-07       Impact factor: 60.633

2.  Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.

Authors:  Ximena Barros-Álvarez; Keshia M Kerchner; Cho Yeow Koh; Stewart Turley; Els Pardon; Jan Steyaert; Ranae M Ranade; J Robert Gillespie; Zhongsheng Zhang; Christophe L M J Verlinde; Erkang Fan; Frederick S Buckner; Wim G J Hol
Journal:  Biochimie       Date:  2017-04-18       Impact factor: 4.079
  2 in total

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