Literature DB >> 11264952

Sperm chromatin structure assay is useful for fertility assessment.

D Evenson1, L Jost.   

Abstract

The Sperm Chromatin Structure Assay (SCSA) serves as a tool for measuring clinically important properties of sperm nuclear chromatin integrity. The assay utilizes the metachromatic features of Acridine Orange (AO), a DNA probe, and the principles of flow cytometry (FCM). SCSA data are not well correlated with classical sperm quality parameters and have been solidly shown to predict sub/infertility. This assay is ideally suited to human and animal fertility clinics to assess male sperm DNA integrity as related to fertility potential and embryo development as well as effects of reproductive toxicants. A detailed description of the SCSA follows.

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Year:  2000        PMID： 11264952     DOI： 10.1023/a:1009844109023

Source DB:  PubMed          Journal:  Methods Cell Sci        ISSN： 1381-5741


  64 in total

Review 1.  Sperm chromatin structure assay (SCSA): a tool in diagnosis and treatment of infertility.

Authors:  Mona Bungum; Leif Bungum; Aleksander Giwercman
Journal:  Asian J Androl       Date:  2010-11-08       Impact factor: 3.285

2.  The effects of vaginal lubricants on sperm function: an in vitro analysis.

Authors:  Alex Mowat; Cora Newton; Clare Boothroyd; Kristy Demmers; Steven Fleming
Journal:  J Assist Reprod Genet       Date:  2014-01-05       Impact factor: 3.412

3.  Can DNA fragmentation of neat or swim-up spermatozoa be used to predict pregnancy following ICSI of fertile oocyte donors?

Authors:  Jaime Gosálvez; Pedro Caballero; Carmen López-Fernández; Leonor Ortega; José Andrés Guijarro; José Luís Fernández; Stephen D Johnston; Rocío Nuñez-Calonge
Journal:  Asian J Androl       Date:  2013-10-14       Impact factor: 3.285

Review 4.  Sperm DNA integrity assays: diagnostic and prognostic challenges and implications in management of infertility.

Authors:  Monis Bilal Shamsi; Syed Nazar Imam; Rima Dada
Journal:  J Assist Reprod Genet       Date:  2011-09-09       Impact factor: 3.412

Review 5.  A systematic review and meta-analysis of spermatozoa cryopreservation, in vitro and in vivo fertility practices in water buffalo.

Authors:  Syed Aftab Hussain Shah; Syed Murtaza Hassan Andrabi
Journal:  Vet Res Commun       Date:  2021-04-30       Impact factor: 2.459

6.  Preliminary examination of polymorphisms of GSTM1, GSTT1, and GSTZ1 in relation to semen quality.

Authors:  Andrew F Olshan; Thomas J Luben; Nancy M Hanley; Sally D Perreault; Ronna L Chan; Amy H Herring; Patricia V Basta; David M DeMarini
Journal:  Mutat Res       Date:  2010-03-07       Impact factor: 2.433

7.  Double-stranded DNA breaks hidden in the neutral Comet assay suggest a role of the sperm nuclear matrix in DNA integrity maintenance.

Authors:  J Ribas-Maynou; J E Gawecka; J Benet; W S Ward
Journal:  Mol Hum Reprod       Date:  2013-11-26       Impact factor: 4.025

8.  The effect of ambient air pollution on sperm quality.

Authors:  Craig Hansen; Thomas J Luben; Jason D Sacks; Andrew Olshan; Susan Jeffay; Lillian Strader; Sally D Perreault
Journal:  Environ Health Perspect       Date:  2010-02       Impact factor: 9.031

9.  Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice.

Authors:  Mirella L Meyer-Ficca; Julia Lonchar; Christine Credidio; Motomasa Ihara; Yun Li; Zhao-Qi Wang; Ralph G Meyer
Journal:  Biol Reprod       Date:  2009-03-04       Impact factor: 4.285

10.  Assessment of sperm quality traits in relation to fertility in boar semen.

Authors:  Neringa Sutkeviciene; Vita Riskeviciene; Aloyzas Januskauskas; Henrikas Zilinskas; Magnus Andersson
Journal:  Acta Vet Scand       Date:  2009-12-16       Impact factor: 1.695
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