Literature DB >> 11264895

Induction of heme oxygenase 1 in liver of spontaneously diabetic rats.

L Cosso1, E P Maineri, N Traverso, N Rosatto, M A Pronzato, D Cottalasso, U M Marinari, P Odetti.   

Abstract

It has been suggested that diabetes induces an increase in oxidative stress; the increased expression of heme-oxygenase 1 (HO-1) in liver is believed to be a sensitive marker of the stress response. The aim of this study was to examine whether diabetes is able to induce HO-1 expression in liver. The specific mRNA was amplified by RT/PCR and calibrated with amplified beta-actin mRNA. The mRNA HO-1 levels in the liver of spontaneously diabetic rats were increased by 1.8 fold compared with non diabetics; this supports the hypothesis of weak but significant oxidative damage due to chronic hyperglycaemia. This work represents the first in vivo study exploring the semi-quantitative expression of HO-1 in the liver of spontaneously diabetic rats.

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Year:  2001        PMID： 11264895     DOI： 10.1080/10715760100300171

Source DB:  PubMed          Journal:  Free Radic Res        ISSN： 1029-2470


  6 in total

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Journal:  Diabetol Metab Syndr       Date:  2013-03-12       Impact factor: 3.320

4.  Heme oxygenase-1 accelerates cutaneous wound healing in mice.

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Journal:  PLoS One       Date:  2009-06-04       Impact factor: 3.240

5.  Astaxanthin Inhibits Expression of Retinal Oxidative Stress and Inflammatory Mediators in Streptozotocin-Induced Diabetic Rats.

Authors:  Po-Ting Yeh; Hsin-Wei Huang; Chung-May Yang; Wei-Shiung Yang; Chang-Hao Yang
Journal:  PLoS One       Date:  2016-01-14       Impact factor: 3.240

6.  Effects of Novel Nitric Oxide-Releasing Molecules against Oxidative Stress on Retinal Pigmented Epithelial Cells.

Authors:  Valeria Pittalà; Annamaria Fidilio; Francesca Lazzara; Chiara Bianca Maria Platania; Loredana Salerno; Roberta Foresti; Filippo Drago; Claudio Bucolo
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  6 in total

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