| Literature DB >> 11264736 |
S Seddigh-Tonekaboni1, W L Lim, B Young, J L Hou, J Waters, K X Luo, H C Thomas, P Karayiannis.
Abstract
Variants of hepatitis B virus (HBV), with amino acid substitutions in the major antigenic "a" determinant of hepatitis B surface antigen (HBsAg), have been described mainly in vaccinated children. In the present study in addition to vaccinated children, we have investigated Chinese blood donors positive for anti-HBc alone, and a patient with continuing liver disease after interferon-induced seroconversion to anti-HBs. Variants were detected in two of four children with break-through infections. One child had a double mutation (P142S and G145R) and the other a G145A substitution. Three of seven anti-HBc positive Chinese blood donors had a T131I substitution, whilst the interferon-treated patient had a treble amino acid substitution (P142S, G145R and N146D). The present results indicate that HBsAg variants may exist in individuals other than vaccinated children.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11264736 DOI： 10.1046/j.1365-2893.2001.00275.x
Source DB: PubMed Journal: J Viral Hepat ISSN： 1352-0504 Impact factor: 3.728