Literature DB >> 11264465

Metabolism of fluorine-containing drugs.

B K Park1, N R Kitteringham, P M O'Neill.   

Abstract

This article reviews current knowledge of the metabolism of drugs that contain fluorine. The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.

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Year:  2001        PMID： 11264465     DOI： 10.1146/annurev.pharmtox.41.1.443

Source DB:  PubMed          Journal:  Annu Rev Pharmacol Toxicol        ISSN： 0362-1642            Impact factor:   13.820


  77 in total

1.  From bifunctional to trifunctional (tricomponent nucleophile-transition metal-lewis acid) catalysis: the catalytic, enantioselective α-fluorination of acid chlorides.

Authors:  Jeremy Erb; Daniel H Paull; Travis Dudding; Lee Belding; Thomas Lectka
Journal:  J Am Chem Soc       Date:  2011-04-22       Impact factor: 15.419

Review 2.  Stable isotope-resolved metabolomics and applications for drug development.

Authors:  Teresa W-M Fan; Pawel K Lorkiewicz; Katherine Sellers; Hunter N B Moseley; Richard M Higashi; Andrew N Lane
Journal:  Pharmacol Ther       Date:  2011-12-23       Impact factor: 12.310

3.  Metabolism of small antimicrobial β(2,2)-amino acid derivatives by murine liver microsomes.

Authors:  Terkel Hansen; Morten K Moe; Trude Anderssen; Morten B Strøm
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2012-03-01       Impact factor: 2.441

4.  Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists.

Authors:  Yijun Huang; Siglinde Wolf; David Koes; Grzegorz M Popowicz; Carlos J Camacho; Tad A Holak; Alexander Dömling
Journal:  ChemMedChem       Date:  2011-09-27       Impact factor: 3.466

5.  Direct arene C-H fluorination with 18F- via organic photoredox catalysis.

Authors:  Wei Chen; Zeng Huang; Nicholas E S Tay; Benjamin Giglio; Mengzhe Wang; Hui Wang; Zhanhong Wu; David A Nicewicz; Zibo Li
Journal:  Science       Date:  2019-06-21       Impact factor: 47.728

6.  Synthesis, ex vivo evaluation, and radiolabeling of potent 1,5-diphenylpyrrolidin-2-one cannabinoid subtype-1 receptor ligands as candidates for in vivo imaging.

Authors:  Sean R Donohue; Joseph H Krushinski; Victor W Pike; Eyassu Chernet; Lee Phebus; Amy K Chesterfield; Christian C Felder; Christer Halldin; John M Schaus
Journal:  J Med Chem       Date:  2008-09-25       Impact factor: 7.446

7.  Deuteration and fluorination of 1,3-bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione to improve its pharmacokinetic properties.

Authors:  Guoyao Xia; Radhia Benmohamed; Richard I Morimoto; Donald R Kirsch; Richard B Silverman
Journal:  Bioorg Med Chem Lett       Date:  2014-09-15       Impact factor: 2.823

8.  Enantioselective Synthesis of Fluoro-Dihydroquinazolones and -Benzooxazinones by Fluorination-Initiated Asymmetric Cyclization Reactions.

Authors:  Kenichi Hiramatsu; Takashi Honjo; Vivek Rauniyar; F Dean Toste
Journal:  ACS Catal       Date:  2015-12-04       Impact factor: 13.084

9.  Broad-Spectrum Antiviral Activity of 3'-Deoxy-3'-Fluoroadenosine against Emerging Flaviviruses.

Authors:  Luděk Eyer; Pavel Svoboda; Jan Balvan; Tomáš Vičar; Matina Raudenská; Michal Štefánik; Jan Haviernik; Ivana Huvarová; Petra Straková; Ivo Rudolf; Zdeněk Hubálek; Katherine Seley-Radtke; Erik de Clercq; Daniel Růžek
Journal:  Antimicrob Agents Chemother       Date:  2021-01-20       Impact factor: 5.191

10.  P1 and P1' para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease.

Authors:  Ravikiran S Yedidi; Zhigang Liu; Iulia A Kovari; Patrick M Woster; Ladislau C Kovari
Journal:  J Mol Graph Model       Date:  2013-11-01       Impact factor: 2.518
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