Y Zhang1, Y Chu, G Chen. 1. Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.
Abstract
OBJECTIVE: To analyze the clinical features and treatment outcomes of autoimmune hemolytic anemia (AIHA). METHODS: Coombs test positive AIHA patients were retrospectively analyzed. RESULTS: Patients with AIHA were predominantly female, secondary AIHA accounted for 49% of the total cases, mainly associated with connective tissue diseases. In most cases of AIHA, the anti-red cell antibodies were IgG plus C3, while patients with IgG plus IgM had more severe clinical manifestations. The response rate of adrenocortical hormones and cyclosporin A (CsA) was 90.9%. CONCLUSION: Adrenocorticosteroids is still the first choice of therapy for AIHA, CsA can improve the response rate.
OBJECTIVE: To analyze the clinical features and treatment outcomes of autoimmune hemolytic anemia (AIHA). METHODS: Coombs test positive AIHA patients were retrospectively analyzed. RESULTS:Patients with AIHA were predominantly female, secondary AIHA accounted for 49% of the total cases, mainly associated with connective tissue diseases. In most cases of AIHA, the anti-red cell antibodies were IgG plus C3, while patients with IgG plus IgM had more severe clinical manifestations. The response rate of adrenocortical hormones and cyclosporin A (CsA) was 90.9%. CONCLUSION: Adrenocorticosteroids is still the first choice of therapy for AIHA, CsA can improve the response rate.