Literature DB >> 11253063

Quantitative trait loci in Drosophila.

T F Mackay1.   

Abstract

Phenotypic variation for quantitative traits results from the simultaneous segregation of alleles at multiple quantitative trait loci. Understanding the genetic architecture of quantitative traits begins with mapping quantitative trait loci to broad genomic regions and ends with the molecular definition of quantitative trait loci alleles. This has been accomplished for some quantitative trait loci in Drosophila. Drosophila quantitative trait loci have sex-, environment- and genotype-specific effects, and are often associated with molecular polymorphisms in non-coding regions of candidate genes. These observations offer valuable lessons to those seeking to understand quantitative traits in other organisms, including humans.

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Year:  2001        PMID： 11253063     DOI： 10.1038/35047544

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  109 in total

1.  Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait loci in outbred half-sib pedigrees: revisiting the location of a quantitative trait locus with major effect on milk production on bovine chromosome 14.

Authors:  Frédéric Farnir; Bernard Grisart; Wouter Coppieters; Juliette Riquet; Paulette Berzi; Nadine Cambisano; Latifa Karim; Myriam Mni; Sirja Moisio; Patricia Simon; Danny Wagenaar; Johanna Vilkki; Michel Georges
Journal:  Genetics       Date:  2002-05       Impact factor: 4.562

2.  Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior.

Authors:  Juan José Fanara; Kellie O Robinson; Stephanie M Rollmann; Robert R H Anholt; Trudy F C Mackay
Journal:  Genetics       Date:  2002-11       Impact factor: 4.562

3.  Functional mapping of quantitative trait loci underlying the character process: a theoretical framework.

Authors:  Chang-Xing Ma; George Casella; Rongling Wu
Journal:  Genetics       Date:  2002-08       Impact factor: 4.562

4.  The genetic architecture of Drosophila sensory bristle number.

Authors:  Christy L Dilda; Trudy F C Mackay
Journal:  Genetics       Date:  2002-12       Impact factor: 4.562

5.  Estimating the distribution of fitness effects from DNA sequence data: implications for the molecular clock.

Authors:  Gwenaël Piganeau; Adam Eyre-Walker
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-18       Impact factor: 11.205

6.  A likelihood approach for mapping growth trajectories using dominant markers in a phase-unknown full-sib family.

Authors:  C-X Ma; M Lin; R C Littell; T Yin; R Wu
Journal:  Theor Appl Genet       Date:  2003-10-28       Impact factor: 5.699

7.  Haplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 gene.

Authors:  Carine Nezer; Catherine Collette; Laurence Moreau; Benoît Brouwers; Jong-Joo Kim; Elisabetta Giuffra; Nadine Buys; Leif Andersson; Michel Georges
Journal:  Genetics       Date:  2003-09       Impact factor: 4.562

8.  Heterogeneous selection at specific loci in natural environments in Arabidopsis thaliana.

Authors:  Cynthia Weinig; Lisa A Dorn; Nolan C Kane; Zachary M German; Solveig S Halldorsdottir; Mark C Ungerer; Yuko Toyonaga; Trudy F C Mackay; Michael D Purugganan; Johanna Schmitt
Journal:  Genetics       Date:  2003-09       Impact factor: 4.562

9.  A large-sample QTL study in mice: I. Growth.

Authors:  Joao L Rocha; Eugene J Eisen; L Dale Van Vleck; Daniel Pomp
Journal:  Mamm Genome       Date:  2004-02       Impact factor: 2.957

10.  Antagonistic pleiotropy for life-history traits at the gene expression level.

Authors:  Zoltán Bochdanovits; Gerdien de Jong
Journal:  Proc Biol Sci       Date:  2004-02-07       Impact factor: 5.349
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