| Literature DB >> 11252956 |
A Poole1, D Penny, B M Sjöberg.
Abstract
Early in the history of DNA, thymine replaced uracil, thus solving a short-term problem for storing genetic information--mutation of cytosine to uracil through deamination. Any engineer would have replaced cytosine, but evolution is a tinkerer not an engineer. By keeping cytosine and replacing uracil the problem was never eliminated, returning once again with the advent of DNA methylation.Entities:
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Year: 2001 PMID： 11252956 DOI： 10.1038/35052091
Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444