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Literature DB >> 11250138

Histone acetyltransferases: function, structure, and catalysis.

Abstract

Histone acetyltransferases (HATs) directly link chromatin modification to gene activation. Recent structure/function studies provide insights into HAT catalysis and histone binding, and genetic studies suggest cross-talk between acetylation and other histone modifications. Developmental aberrations in mice and certain human cancers are associated with HAT mutations, further highlighting the importance of these enzymes to normal cell growth and differentiation.

Entities: Disease Species

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Year: 2001 PMID： 11250138 DOI： 10.1016/s0959-437x(00)00173-8

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

117 in total

1. The PHD type zinc finger is an integral part of the CBP acetyltransferase domain.

Authors: Eric Kalkhoven; Hans Teunissen; Ada Houweling; C Peter Verrijzer; Alt Zantema
Journal: Mol Cell Biol Date: 2002-04 Impact factor: 4.272

2. Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation.

Authors: Gaëlle Legube; Laetitia K Linares; Claudie Lemercier; Martin Scheffner; Saadi Khochbin; Didier Trouche
Journal: EMBO J Date: 2002-04-02 Impact factor: 11.598

3. The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells.

Authors: Ke Long Jin; Jeong-Yeol Park; Eun Joo Noh; Kwang Lae Hoe; Joo Hak Lee; Jong-Hyeok Kim; Joo-Hyun Nam
Journal: J Gynecol Oncol Date: 2010-12-31 Impact factor: 4.401

Review 4. Regulating histone acetyltransferases and deacetylases.

Authors: Gaëlle Legube; Didier Trouche
Journal: EMBO Rep Date: 2003-10 Impact factor: 8.807

5. Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation.

Authors: Jean-Bernard Lazaro; Peter J Bailey; Andrew B Lassar
Journal: Genes Dev Date: 2002-07-15 Impact factor: 11.361

Histone acetyltransferases: function, structure, and catalysis.

1. The PHD type zinc finger is an integral part of the CBP acetyltransferase domain.

2. Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation.

3. The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells.

Review 4. Regulating histone acetyltransferases and deacetylases.

5. Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation.

Review 6. Chromatin dynamics and Arabidopsis development.

Review 7. Epigenetic mechanisms in cardiac development and disease.

Review 8. The redox basis of epigenetic modifications: from mechanisms to functional consequences.

9. Chaperone-mediated acetylation of histones by Rtt109 identified by quantitative proteomics.

Review 10. Epigenetic system: a pathway to malignancies and a therapeutic target.