Literature DB >> 11248557

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

D Durocher1, S P Jackson.   

Abstract

The DNA damage signalling pathway is a core element of the cellular response to genotoxic insult, and its components play key roles in defending against neoplastic transformation. Recent work has indicated that the human ATM and ATR proteins, and their yeast homologues, are intimately involved in sensing DNA damage, suggesting parallels with the DNA double-strand break repair enzyme DNA-PK.

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Year:  2001        PMID： 11248557     DOI： 10.1016/s0955-0674(00)00201-5

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  159 in total

1.  Preferential binding of ATR protein to UV-damaged DNA.

Authors:  Keziban Unsal-Kaçmaz; Alexander M Makhov; Jack D Griffith; Aziz Sancar
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-14       Impact factor: 11.205

2.  Synapsis of DNA ends by DNA-dependent protein kinase.

Authors:  Lisa G DeFazio; Rachel M Stansel; Jack D Griffith; Gilbert Chu
Journal:  EMBO J       Date:  2002-06-17       Impact factor: 11.598

3.  A quantitative assay for telomere protection in Saccharomyces cerevisiae.

Authors:  Michelle L DuBois; Zara W Haimberger; Martin W McIntosh; Daniel E Gottschling
Journal:  Genetics       Date:  2002-07       Impact factor: 4.562

4.  Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities.

Authors:  Keziban Unsal-Kaçmaz; Aziz Sancar
Journal:  Mol Cell Biol       Date:  2004-02       Impact factor: 4.272

Review 5.  Cellular senescence in cancer treatment: friend or foe?

Authors:  Pascal Kahlem; Bernd Dörken; Clemens A Schmitt
Journal:  J Clin Invest       Date:  2004-01       Impact factor: 14.808

6.  Integrated signaling in developing lymphocytes: the role of DNA damage responses.

Authors:  Jeffrey J Bednarski; Barry P Sleckman
Journal:  Cell Cycle       Date:  2012-10-03       Impact factor: 4.534

7.  Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.

Authors:  Doug W Chan; Benjamin Ping-Chi Chen; Sheela Prithivirajsingh; Akihiro Kurimasa; Michael D Story; Jun Qin; David J Chen
Journal:  Genes Dev       Date:  2002-09-15       Impact factor: 11.361

8.  Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

Authors:  Gopal P Sapkota; Maria Deak; Agnieszka Kieloch; Nick Morrice; Aaron A Goodarzi; Carl Smythe; Yosef Shiloh; Susan P Lees-Miller; Dario R Alessi
Journal:  Biochem J       Date:  2002-12-01       Impact factor: 3.857

9.  Involvement of ATM/ATR-p38 MAPK cascade in MNNG induced G1-S arrest.

Authors:  Ke-Qing Zhu; Suo-Jiang Zhang
Journal:  World J Gastroenterol       Date:  2003-09       Impact factor: 5.742

10.  SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage.

Authors:  Seong Won Lee; Moon Hee Lee; Jong Ho Park; Sung Hwan Kang; Hee Min Yoo; Seung Hyun Ka; Young Mi Oh; Young Joo Jeon; Chin Ha Chung
Journal:  EMBO J       Date:  2012-10-23       Impact factor: 11.598
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