| Literature DB >> 11248065 |
G H Su1, R Bansal, K M Murphy, E Montgomery, C J Yeo, R H Hruban, S E Kern.
Abstract
DPC4 is known to mediate signals initiated by type beta transforming growth factor (TGFbeta) as well as by other TGFbeta superfamily ligands such as activin and BMP (bone morphogenic proteins), but mutational surveys of such non-TGFbeta receptors have been negative to date. Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene.Entities:
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Year: 2001 PMID： 11248065 PMCID： PMC30640 DOI： 10.1073/pnas.051484398
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205