Literature DB >> 11243209

[Effects of neferine on platelet aggregation in rabbits].

J Yu1, W S Hu.   

Abstract

Neferine (Nef), a hypotensive agent with antiarrythmic action, is a dibenzyl isoquinoline alkaloid isolated from a Chinese medicinal herb (Nelumbo nucifera Gaertn). Its effects on platelet aggregation and TXA2/PGI2 and cAMP/cGMP balance were studied with methods of turbidimetry and RIA. Nef was shown to significantly inhibit rabbit platelet aggregation induced by ADP, collagen, arachidonic acid (AA) and platelet-activating factor (PAF) with IC50 of 16, 22, 193 and 103 mumol.L-1, respectively. Nef was found to increase vascular 6-keto-PGF1 alpha and platelet cAMP levels in dose-dependent manner, but inhibit AA stimulated TXA2 release from platelets. Nef showed no significant effect on the platelet cGMP level. The results suggest that the mechanism of Nef on platelet aggregation is related to regulation of TXA2/PGI2 and cAMP/cGMP balance.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 11243209

Source DB:  PubMed          Journal:  Yao Xue Xue Bao        ISSN： 0513-4870


  8 in total

1.  Synthesis of silver nanoparticles using Nelumbo nucifera leaf extract and its larvicidal activity against malaria and filariasis vectors.

Authors:  Thirunavukkarasu Santhoshkumar; Abdul Abdul Rahuman; Govindasamy Rajakumar; Sampath Marimuthu; Asokan Bagavan; Chidambaram Jayaseelan; Abdul Abduz Zahir; Gandhi Elango; Chinnaperumal Kamaraj
Journal:  Parasitol Res       Date:  2010-10-27       Impact factor: 2.289

2.  Anticancer activities of alkaloids extracted from the Ba lotus seed in human nasopharyngeal carcinoma CNE-1 cells.

Authors:  Xin Zhao; Xia Feng; Deguang Peng; Weiwei Liu; Peng Sun; Guijie Li; Lianjie Gu; Jia-Le Song
Journal:  Exp Ther Med       Date:  2016-09-20       Impact factor: 2.447

3.  Neferine inhibits angiotensin II-stimulated proliferation in vascular smooth muscle cells through heme oxygenase-1.

Authors:  Xiao-chun Li; Guo-xin Tong; Yu Zhang; Shan-xin Liu; Qi-hui Jin; Huai-hong Chen; Peng Chen
Journal:  Acta Pharmacol Sin       Date:  2010-06       Impact factor: 6.150

4.  Effects of neferine on retinal tissue in experimental diabetic rat model.

Authors:  Mehmet Cevik; Hamidu Hamisi Gobeka; Orhan Aydemir
Journal:  Int Ophthalmol       Date:  2022-07-19       Impact factor: 2.029

5.  Neferine prevented hyperglycemia-induced endothelial cell apoptosis through suppressing ROS/Akt/NF-κB signal.

Authors:  Guoying Guan; Hui Han; Yuling Yang; Yimin Jin; Xueting Wang; Xiaomin Liu
Journal:  Endocrine       Date:  2014-03-04       Impact factor: 3.633

Review 6.  Phytochemical Profile and Biological Activity of Nelumbo nucifera.

Authors:  Keshav Raj Paudel; Nisha Panth
Journal:  Evid Based Complement Alternat Med       Date:  2015-12-30       Impact factor: 2.629

7.  The anti-tumor activities of Neferine on cell invasion and oxaliplatin sensitivity regulated by EMT via Snail signaling in hepatocellular carcinoma.

Authors:  Ganlu Deng; Shan Zeng; Junli Ma; Yan Zhang; Yanling Qu; Ying Han; Ling Yin; Changjing Cai; Cao Guo; Hong Shen
Journal:  Sci Rep       Date:  2017-01-30       Impact factor: 4.379

Review 8.  Research Progress on Natural Products' Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels.

Authors:  Jinshan He; Sicong Li; Yumeng Ding; Yujia Tong; Xuebin Li
Journal:  Cardiovasc Ther       Date:  2022-03-22       Impact factor: 3.023
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.