Literature DB >> 11240137

In vitro glucuronidation of xanthohumol, a flavonoid in hop and beer, by rat and human liver microsomes.

M Yilmazer1, J F Stevens, D R Buhler.   

Abstract

Xanthohumol (XN) is the major prenylated flavonoid of hop plants and has been detected in beer. Previous studies suggest a variety of potential cancer chemopreventive effects for XN, but there is no information on its metabolism. The aim of this study was to investigate in vitro glucuronidation of XN by rat and human liver microsomes. Using high-performance liquid chromatography, two major glucuronides of XN were found with either rat or human liver microsomes. Release of the aglycone by enzymatic hydrolysis with beta-glucuronidase followed by liquid chromatography/mass spectrometry and nuclear magnetic resonance analysis revealed that these were C-4' and C-4 monoglucuronides of XN.

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Year:  2001        PMID： 11240137     DOI： 10.1016/s0014-5793(01)02210-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  15 in total

1.  Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.

Authors:  LeeCole Legette; Lian Ma; Ralph L Reed; Cristobal L Miranda; John Mark Christensen; Rosita Rodriguez-Proteau; Jan F Stevens
Journal:  Mol Nutr Food Res       Date:  2011-12-07       Impact factor: 5.914

Review 2.  The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties.

Authors:  L R Chadwick; G F Pauli; N R Farnsworth
Journal:  Phytomedicine       Date:  2005-07-01       Impact factor: 5.340

Review 3.  First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics.

Authors:  Baojian Wu; Kaustubh Kulkarni; Sumit Basu; Shuxing Zhang; Ming Hu
Journal:  J Pharm Sci       Date:  2011-04-11       Impact factor: 3.534

4.  Maternal prenatal cigarette, alcohol and illicit drug use and risk of infant leukaemia: a report from the Children's Oncology Group.

Authors:  Megan E Slater; Amy M Linabery; Cindy K Blair; Logan G Spector; Nyla A Heerema; Leslie L Robison; Julie A Ross
Journal:  Paediatr Perinat Epidemiol       Date:  2011-08-10       Impact factor: 3.980

5.  Disposition of hop prenylflavonoids in human breast tissue.

Authors:  Selin Bolca; Jinghu Li; Dejan Nikolic; Nathalie Roche; Phillip Blondeel; Sam Possemiers; Denis De Keukeleire; Marc Bracke; Arne Heyerick; Richard B van Breemen; Herman Depypere
Journal:  Mol Nutr Food Res       Date:  2010-07       Impact factor: 5.914

6.  In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.).

Authors:  Dejan Nikolic; Yongmei Li; Lucas R Chadwick; Richard B van Breemen
Journal:  Pharm Res       Date:  2006-05-16       Impact factor: 4.200

7.  Xanthohumol Pyrazole Derivative Improves Diet-Induced Obesity and Induces Energy Expenditure in High-Fat Diet-Fed Mice.

Authors:  Ines L Paraiso; Luce M Mattio; Armando Alcázar Magaña; Jaewoo Choi; Layhna S Plagmann; Margaret A Redick; Cristobal L Miranda; Claudia S Maier; Sabrina Dallavalle; Chrissa Kioussi; Paul R Blakemore; Jan F Stevens
Journal:  ACS Pharmacol Transl Sci       Date:  2021-11-04

8.  Pharmacokinetic Interactions of a Hop Dietary Supplement with Drug Metabolism in Perimenopausal and Postmenopausal Women.

Authors:  Richard B van Breemen; Luying Chen; Alyssa Tonsing-Carter; Suzanne Banuvar; Elena Barengolts; Marlos Viana; Shao-Nong Chen; Guido F Pauli; Judy L Bolton
Journal:  J Agric Food Chem       Date:  2020-04-24       Impact factor: 5.279

Review 9.  High-performance liquid chromatography-tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites.

Authors:  M Holcapek; L Kolárová; M Nobilis
Journal:  Anal Bioanal Chem       Date:  2008-03-15       Impact factor: 4.142

10.  METLIN: A Technology Platform for Identifying Knowns and Unknowns.

Authors:  Carlos Guijas; J Rafael Montenegro-Burke; Xavier Domingo-Almenara; Amelia Palermo; Benedikt Warth; Gerrit Hermann; Gunda Koellensperger; Tao Huan; Winnie Uritboonthai; Aries E Aisporna; Dennis W Wolan; Mary E Spilker; H Paul Benton; Gary Siuzdak
Journal:  Anal Chem       Date:  2018-02-09       Impact factor: 6.986
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