BACKGROUND: Although gender is known to be an independent predictor of 30-day operative mortality (OM) after coronary artery bypass grafting, the purpose of this study was to determine whether race-alone or in combination with gender-affects OM. METHODS: For 1994 to 1996, The Society of Thoracic Surgeons database records for 441,542 coronary artery bypass grafting-only procedures were analyzed. Baseline annual multivariate models were built. Gender and race were added to each model. Risk-adjusted OM rates were then calculated for race, gender, and their combination. Patients were also stratified into groups of comparable predicted OM to allow for a direct comparison of risk-matched Caucasians and non-Caucasians. RESULTS: Of the procedures, 28.2% were on women and 8.5% on non-Caucasians. Overall, OM was 3.29%. Multivariate risk-adjusted OM varied by gender and race (p < 0.10). Risk-adjusted OM rates (with 95% confidence intervals) were 4.0% (3.9% to 4.1%) for females and 3.2% (3.2% to 3.3%) for males. Risk-adjusted OM rates were 3.9% (3.7% to 4.1%) for non-Caucasians and 3.3% (3.2% to 3.3%) for Caucasians. Among equally risk-matched Caucasians and non-Caucasians, non-Caucasians had significantly higher (p < 0.005) mortality among the lower risk subgroups (up to 10% predicted OM) but not among the higher risk subgroups. CONCLUSIONS: Race and gender are independent predictors of adverse outcome following coronary artery bypass grafting, holding all other risk factors constant.
BACKGROUND: Although gender is known to be an independent predictor of 30-day operative mortality (OM) after coronary artery bypass grafting, the purpose of this study was to determine whether race-alone or in combination with gender-affects OM. METHODS: For 1994 to 1996, The Society of Thoracic Surgeons database records for 441,542 coronary artery bypass grafting-only procedures were analyzed. Baseline annual multivariate models were built. Gender and race were added to each model. Risk-adjusted OM rates were then calculated for race, gender, and their combination. Patients were also stratified into groups of comparable predicted OM to allow for a direct comparison of risk-matched Caucasians and non-Caucasians. RESULTS: Of the procedures, 28.2% were on women and 8.5% on non-Caucasians. Overall, OM was 3.29%. Multivariate risk-adjusted OM varied by gender and race (p < 0.10). Risk-adjusted OM rates (with 95% confidence intervals) were 4.0% (3.9% to 4.1%) for females and 3.2% (3.2% to 3.3%) for males. Risk-adjusted OM rates were 3.9% (3.7% to 4.1%) for non-Caucasians and 3.3% (3.2% to 3.3%) for Caucasians. Among equally risk-matched Caucasians and non-Caucasians, non-Caucasians had significantly higher (p < 0.005) mortality among the lower risk subgroups (up to 10% predicted OM) but not among the higher risk subgroups. CONCLUSIONS: Race and gender are independent predictors of adverse outcome following coronary artery bypass grafting, holding all other risk factors constant.
Authors: Chiara Romualdi; David Balding; Ivane S Nasidze; Gregory Risch; Myles Robichaux; Stephen T Sherry; Mark Stoneking; Mark A Batzer; Guido Barbujani Journal: Genome Res Date: 2002-04 Impact factor: 9.043
Authors: Saswata Deb; Jack V Tu; Peter C Austin; Dennis T Ko; Rodolfo Rocha; C David Mazer; Alex Kiss; Stephen E Fremes Journal: J Am Heart Assoc Date: 2016-07-22 Impact factor: 5.501
Authors: Eric Anderson; Matthew Glogoza; Aaron Bettenhausen; Rory Guenther; Dylan Dangerfield; Rick Jansen; Roxanne Newman; Donald Warne; Cornelius Dyke Journal: Health Equity Date: 2018-08-01