Literature DB >> 11229742

Synthesis and biological evaluation of DNA targeting flexible side-chain substituted beta-carboline derivatives.

S Xiao1, W Lin, C Wang, M Yang.   

Abstract

A series of 3-substituted-beta-carboline derivatives was synthesized from L-tryptophan. The intercalating binding mode of these compounds with DNA, the effects of the flexible alkylamine side chain on the intercalating ability and their antitumor activity were studied, which agreed well with the molecular modeling results.

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Year:  2001        PMID： 11229742     DOI： 10.1016/s0960-894x(00)00679-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  A spectroscopic study of the interaction of the fluorescent beta-carboline-3-carboxylic acid N-methylamide with DNA constituents: nucleobases, nucleosides and nucleotides.

Authors:  Iñigo X García-Zubiri; Hugh D Burrows; Joao S Seixas de Melo; María Monteserín; Antonio Arroyo; María J Tapia
Journal:  J Fluoresc       Date:  2008-05-11       Impact factor: 2.217

2.  Synthesis of the carboline disaccharide domain of shishijimicin A.

Authors:  K C Nicolaou; J L Kiappes; Weiwei Tian; Vijaya B Gondi; Jochen Becker
Journal:  Org Lett       Date:  2011-06-28       Impact factor: 6.005

3.  Cyclometalated Ru(II) β-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling.

Authors:  Jincan Chen; Yuanyuan Deng; Jie Wang; Suxiang Chen; Fa Peng; Xuerong He; Meijun Liu; Hui Luo; Jingjing Zhang; Lanmei Chen
Journal:  J Biol Inorg Chem       Date:  2021-08-30       Impact factor: 3.358

4.  Quinoline alkaloids as intercalative topoisomerase inhibitors.

Authors:  Kendall G Byler; Chen Wang; William N Setzer
Journal:  J Mol Model       Date:  2009-05-08       Impact factor: 1.810

5.  Synthesis and In Vitro Antitumor Activity of Novel Bivalent β-Carboline-3-carboxylic Acid Derivatives with DNA as a Potential Target.

Authors:  Hongling Gu; Na Li; Jiangkun Dai; Yaxi Xi; Shijun Wang; Junru Wang
Journal:  Int J Mol Sci       Date:  2018-10-15       Impact factor: 5.923

6.  Sequence specific binding of beta carboline alkaloid harmalol with deoxyribonucleotides: binding heterogeneity, conformational, thermodynamic and cytotoxic aspects.

Authors:  Sarita Sarkar; Prateek Pandya; Kakali Bhadra
Journal:  PLoS One       Date:  2014-09-23       Impact factor: 3.240
  6 in total

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