RATIONALE AND OBJECTIVES: To develop a validated post-processing routine for volumetry of the ventilated airspaces by 3He MRI. METHODS: 3Helium MRI and pulmonary function tests were performed in seven healthy volunteers. After segmentation of ventilated airspaces, their volumes were calculated. Functional residual capacity (FRC) was used as a reference. For comparison of absolute volumes, correction factors were evaluated. RESULTS: Mean lung volume (+/- standard deviation) calculated from 3He MRI was 4,082 +/- 908 mL and mean FRC was 3,696 +/- 1166 mL, with a mean difference of 386 mL (r = 0.88). After correction for the relative pulmonary air content (factor 0.82), posture (0.72), and the individual tidal volume, 3He MRI volume was 3,348 +/- 744 mL and mean FRC was 3,422 +/- 817 mL, with the mean difference down to -74 mL (r = 0.9). Comparison on an individual basis confirmed an improvement in the estimation of absolute lung volume. CONCLUSIONS: Volumetry of ventilated lung from 3He MRI shows high correlation and good agreement with the results of pulmonary function tests.
RATIONALE AND OBJECTIVES: To develop a validated post-processing routine for volumetry of the ventilated airspaces by 3He MRI. METHODS: 3Helium MRI and pulmonary function tests were performed in seven healthy volunteers. After segmentation of ventilated airspaces, their volumes were calculated. Functional residual capacity (FRC) was used as a reference. For comparison of absolute volumes, correction factors were evaluated. RESULTS: Mean lung volume (+/- standard deviation) calculated from 3He MRI was 4,082 +/- 908 mL and mean FRC was 3,696 +/- 1166 mL, with a mean difference of 386 mL (r = 0.88). After correction for the relative pulmonary air content (factor 0.82), posture (0.72), and the individual tidal volume, 3He MRI volume was 3,348 +/- 744 mL and mean FRC was 3,422 +/- 817 mL, with the mean difference down to -74 mL (r = 0.9). Comparison on an individual basis confirmed an improvement in the estimation of absolute lung volume. CONCLUSIONS: Volumetry of ventilated lung from 3He MRI shows high correlation and good agreement with the results of pulmonary function tests.
Authors: Klaus Kurt Gast; Julia Zaporozhan; Sebastian Ley; Alexander Biedermann; Frank Knitz; Balthasar Eberle; Joerg Schmiedeskamp; Claus-Peter Heussel; Eckhard Mayer; Wolfgang Günter Schreiber; Manfred Thelen; Hans-Ulrich Kauczor Journal: Eur Radiol Date: 2003-10-16 Impact factor: 5.315
Authors: Robert P Thomen; Ajay Sheshadri; James D Quirk; Jim Kozlowski; Henry D Ellison; Rhonda D Szczesniak; Mario Castro; Jason C Woods Journal: Radiology Date: 2014-08-19 Impact factor: 11.105
Authors: Kiarash Emami; Elaine Chia; Stephen Kadlecek; John P Macduffie-Woodburn; Jianliang Zhu; Stephen Pickup; Allison Blum; Masaru Ishii; Rahim R Rizi Journal: J Appl Physiol (1985) Date: 2010-09-30
Authors: Tokihiro Yamamoto; Sven Kabus; Cristian Lorenz; Erik Mittra; Julian C Hong; Melody Chung; Neville Eclov; Jacqueline To; Maximilian Diehn; Billy W Loo; Paul J Keall Journal: Int J Radiat Oncol Biol Phys Date: 2014-08-04 Impact factor: 7.038
Authors: Christian Plathow; Christian Fink; Sebastian Ley; Michael Puderbach; Monica Eichinger; Astrid Schmähl; Hans-Ulrich Kauczor Journal: Eur Radiol Date: 2004-05-01 Impact factor: 5.315