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Literature DB >> 11224536

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.

H Cai¹, Y Wang, D McCarthy, H Wen, D R Borchelt, D L Price, P C Wong.

Abstract

Entities: Gene

Mesh：

Substances：

Year: 2001 PMID： 11224536 DOI： 10.1038/85064

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

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349 in total

1. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.

Authors: S Kitazume; Y Tachida; R Oka; K Shirotani; T C Saido; Y Hashimoto
Journal: Proc Natl Acad Sci U S A Date: 2001-11-06 Impact factor: 11.205

Review 2. Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease.

Authors: C Dingwall
Journal: J Clin Invest Date: 2001-11 Impact factor: 14.808

3. BACE1 gene promoter single-nucleotide polymorphisms in Alzheimer's disease.

Authors: Weihui Zhou; Fang Cai; Yu Li; George S Yang; Kathleen D O'Connor; Robert A Holt; Weihong Song
Journal: J Mol Neurosci Date: 2010-05-09 Impact factor: 3.444

Review 4. Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease.

Authors: Vivian Hook; Gregory Hook; Mark Kindy
Journal: Biol Chem Date: 2010-08 Impact factor: 3.915

Review 5. Mouse models of Alzheimer's disease.

Authors: Alicia M Hall; Erik D Roberson
Journal: Brain Res Bull Date: 2011-11-28 Impact factor: 4.077

6. BACE2 expression increases in human neurodegenerative disease.

Authors: Christopher J Holler; Robin L Webb; Ashley L Laux; Tina L Beckett; Dana M Niedowicz; Rachel R Ahmed; Yinxing Liu; Christopher R Simmons; Amy L S Dowling; Angela Spinelli; Moshe Khurgel; Steven Estus; Elizabeth Head; Louis B Hersh; M Paul Murphy
Journal: Am J Pathol Date: 2011-11-07 Impact factor: 4.307

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.

1. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.

Review 2. Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease.

3. BACE1 gene promoter single-nucleotide polymorphisms in Alzheimer's disease.

Review 4. Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease.

Review 5. Mouse models of Alzheimer's disease.

6. BACE2 expression increases in human neurodegenerative disease.

Review 7. Flavonoids as therapeutic compounds targeting key proteins involved in Alzheimer's disease.

8. BACE1 levels by APOE genotype in non-demented and Alzheimer's post-mortem brains.

9. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.

Review 10. Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development.