Literature DB >> 11222731

Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta.

A Manninen1, P Huotari, M Hiipakka, G H Renkema, K Saksela.   

Abstract

Here we show that the potential to regulate NFAT is a conserved property of different Nef alleles and that Nef residues involved in membrane targeting and SH3 binding are critical for this function. Cotransfection of an activated protein kinase C-theta (PKC-theta) with Nef implicated PKC-theta as a possible physiological cofactor of Nef in promoting NFAT-dependent gene expression and T-cell activation.

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Year:  2001        PMID： 11222731      PMCID： PMC115932          DOI： 10.1128/JVI.75.6.3034-3037.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway.

Authors:  A Manninen; G H Renkema; K Saksela
Journal:  J Biol Chem       Date:  2000-06-02       Impact factor: 5.157

2.  A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.

Authors:  M Villalba; N Coudronniere; M Deckert; E Teixeiro; P Mas; A Altman
Journal:  Immunity       Date:  2000-02       Impact factor: 31.745

3.  Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions.

Authors:  L X Liu; N Heveker; O T Fackler; S Arold; S Le Gall; K Janvier; B M Peterlin; C Dumas; O Schwartz; S Benichou; R Benarous
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

Review 4.  Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters.

Authors:  M G Kazanietz
Journal:  Mol Carcinog       Date:  2000-05       Impact factor: 4.784

5.  Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.

Authors:  A Adachi; H E Gendelman; S Koenig; T Folks; R Willey; A Rabson; M A Martin
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103

6.  Characterization and molecular basis of the oligomeric structure of HIV-1 nef protein.

Authors:  S Arold; F Hoh; S Domergue; C Birck; M A Delsuc; M Jullien; C Dumas
Journal:  Protein Sci       Date:  2000-06       Impact factor: 6.725

7.  Identification of the Nef-associated kinase as p21-activated kinase 2.

Authors:  G H Renkema; A Manninen; D A Mann; M Harris; K Saksela
Journal:  Curr Biol       Date:  1999-12-02       Impact factor: 10.834

8.  A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.

Authors:  P A Bresnahan; W Yonemoto; S Ferrell; D Williams-Herman; R Geleziunas; W C Greene
Journal:  Curr Biol       Date:  1998-11-05       Impact factor: 10.834

9.  Clonal selection of human immunodeficiency virus (HIV): serological differences in the envelope antigens of the cloned viruses and HIV prototypes (HTLV-III B, LAV, and ARV).

Authors:  S Harada; N Kobayashi; Y Koyanagi; N Yamamoto
Journal:  Virology       Date:  1987-06       Impact factor: 3.616

10.  Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.

Authors:  J A Levy; A D Hoffman; S M Kramer; J A Landis; J M Shimabukuro; L S Oshiro
Journal:  Science       Date:  1984-08-24       Impact factor: 47.728
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  20 in total

Review 1.  Emerging and diverse roles of protein kinase C in immune cell signalling.

Authors:  Seng-Lai Tan; Peter J Parker
Journal:  Biochem J       Date:  2003-12-15       Impact factor: 3.857

2.  Activation of nuclear factor of activated T cells by human T-lymphotropic virus type 1 accessory protein p12(I).

Authors:  Björn Albrecht; Celine D D'Souza; Wei Ding; Susheela Tridandapani; K Mark Coggeshall; Michael D Lairmore
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

3.  Human T-cell lymphotropic virus type 1 p12I enhances interleukin-2 production during T-cell activation.

Authors:  Wei Ding; Seung-Jae Kim; Amrithraj M Nair; Bindhu Michael; Kathleen Boris-Lawrie; Adam Tripp; Gerold Feuer; Michael D Lairmore
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

4.  Endothelial cells promote human immunodeficiency virus replication in nondividing memory T cells via Nef-, Vpr-, and T-cell receptor-dependent activation of NFAT.

Authors:  Jaehyuk Choi; Jason Walker; Kristina Talbert-Slagle; Paulette Wright; Jordan S Pober; Louis Alexander
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

5.  Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef.

Authors:  Shailendra K Saxena; Gaurav Shrivastava; Sneham Tiwari; Ml Arvinda Swamy; Madhavan Pn Nair
Journal:  Future Virol       Date:  2012-06-01       Impact factor: 1.831

Review 6.  Critical role of human T-lymphotropic virus type 1 accessory proteins in viral replication and pathogenesis.

Authors:  Björn Albrecht; Michael D Lairmore
Journal:  Microbiol Mol Biol Rev       Date:  2002-09       Impact factor: 11.056

7.  Multi-transmembrane protein K15 of Kaposi's sarcoma-associated herpesvirus targets Lyn kinase in the membrane raft and induces NFAT/AP1 activities.

Authors:  Nam-Hyuk Cho; Young-Ki Choi; Joong-Kook Choi
Journal:  Exp Mol Med       Date:  2008-10-31       Impact factor: 8.718

8.  CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease.

Authors:  Xiaoduan Weng; Elena Priceputu; Pavel Chrobak; Johanne Poudrier; Denis G Kay; Zaher Hanna; Tak W Mak; Paul Jolicoeur
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

Review 9.  Role of accessory proteins of HTLV-1 in viral replication, T cell activation, and cellular gene expression.

Authors:  Michael Bindhu; Amrithraj Nair; Michael D Lairmore
Journal:  Front Biosci       Date:  2004-09-01

10.  The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.

Authors:  Nathalie Arhel; Martin Lehmann; Karen Clauss; G Ulrich Nienhaus; Vincent Piguet; Frank Kirchhoff
Journal:  J Clin Invest       Date:  2009-09-14       Impact factor: 14.808
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