Literature DB >> 11219860

Metabolic activation of benzo[a]pyrene by a human hepatoma cell line.

L Diamond1, F Kruszewski, D P Aden, B B Knowles, W M Baird.   

Abstract

The liver-derived human cell line, Hep G2, has high benzo[a]pyrene-metabolizing activity and converts benzo[a]pyrene to intermediates that are mutagenic and that bind to DNA. This cell line will be useful for studying metabolic activation of polycyclic aromatic hydrocarbons and other xenobiotics by human tissue and as an activation system in short-term screening assays for identifying compounds with carcinogenic potential for humans.

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Year:  1980        PMID： 11219860     DOI： 10.1093/carcin/1.10.871

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  11 in total

1.  Use of established hepatoma cell lines in biotoxicology.

Authors:  M Ferro; A M Bassi; S Penco; G Nanni
Journal:  Cytotechnology       Date:  1993-01       Impact factor: 2.058

2.  Induction of haem synthesis in Hep G2 human hepatoma cells by dimethyl sulphoxide. A transcriptionally activated event.

Authors:  R A Galbraith; S Sassa; A Kappas
Journal:  Biochem J       Date:  1986-07-15       Impact factor: 3.857

3.  Expression and distribution of symplekin regulates the assembly and function of the epithelial tight junction.

Authors:  Hong Chang; Chen Zhang; Yi Cao
Journal:  Histochem Cell Biol       Date:  2012-01-05       Impact factor: 4.304

4.  Study of the in vitro bioactivation of albendazole in human liver microsomes and hepatoma cell lines.

Authors:  S Rolin; H Souhaili-el Amri; A M Batt; M Levy; D Bagrel; G Siest
Journal:  Cell Biol Toxicol       Date:  1989-01       Impact factor: 6.691

5.  Expression of cathepsin B and aryl hydrocarbon hydroxylase activities, and of apolipoprotein B in human hepatoma cells maintained long-term in a serum-free medium.

Authors:  M Dufresne; D Jane; A Theriault; K Adeli
Journal:  In Vitro Cell Dev Biol Anim       Date:  1993-11       Impact factor: 2.416

6.  Acute cytotoxicities of polynuclear aromatic hydrocarbons determined in vitro with the human liver tumor cell line, HepG2.

Authors:  H Babich; M K Sardana; E Borenfreund
Journal:  Cell Biol Toxicol       Date:  1988-09       Impact factor: 6.691

7.  Use of an established human hepatoma cell line with endogenous bioactivation for gene mutation studies.

Authors:  G Chang; D Jacobson-Kram; J R Williams
Journal:  Cell Biol Toxicol       Date:  1988-09       Impact factor: 6.691

8.  Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1 in human hepatomas.

Authors:  Peirong Lu; Yasunari Nakamoto; Yoko Nemoto-Sasaki; Chifumi Fujii; Hui Wang; Minako Hashii; Yasukazu Ohmoto; Shuichi Kaneko; Kenichi Kobayashi; Naofumi Mukaida
Journal:  Am J Pathol       Date:  2003-04       Impact factor: 4.307

9.  Pathways for the mutagenesis of 1-nitropyrene and dinitropyrenes in the human hepatoma cell line HepG2.

Authors:  K J Silvers; E P Eddy; E C McCoy; H S Rosenkranz; P C Howard
Journal:  Environ Health Perspect       Date:  1994-10       Impact factor: 9.031

10.  An association study on genetic polymorphisms of Rab37 gene with the risk of esophageal squamous cell carcinoma in a Chinese Han population.

Authors:  Xiaofeng Xu; Xingying Guan; Huansheng Tao; Kang Yang; Yun Bai
Journal:  Int J Med Sci       Date:  2013-01-18       Impact factor: 3.738
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