Literature DB >> 11215887

High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on polysaccharide-type chiral stationary phases.

H Y Aboul-Enein1.   

Abstract

Enantioseparation of drugs with multiple chiral centers is challenging. This article describes resolution of some drugs with multiple chiral centers using polysaccharide-type chiral stationary phases. Also, the use of the column-switching technique is demonstrated to achieve the resolution of this type of compounds.

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Year:  2001        PMID： 11215887     DOI： 10.1016/s0021-9673(00)00950-x

Source DB:  PubMed          Journal:  J Chromatogr A        ISSN： 0021-9673            Impact factor:   4.759


  6 in total

1.  A Validated RP-HPLC Method for Simultaneous Estimation of Nebivolol and Hydrochlorothiazide in Tablets.

Authors:  S N Meyyanathan; S Rajan; S Muralidharan; Arunadevi S Birajdar; B Suresh
Journal:  Indian J Pharm Sci       Date:  2008-09       Impact factor: 0.975

2.  Isolation and evaluation of the enantiospecific antitubercular activity of a novel triazole compound.

Authors:  Radha Shekar; Barij Nayan Sinha; Arindam Mukhopadhya; Mariam S Degani
Journal:  Sci Pharm       Date:  2013-10-21

3.  Achiral Molecular Recognition of Aromatic Position Isomers by Polysaccharide-Based CSPs in Relation to Chiral Recognition.

Authors:  Tohru Shibata; Satoshi Shinkura; Atsushi Ohnishi; Kazuyoshi Ueda
Journal:  Molecules       Date:  2016-12-28       Impact factor: 4.411

4.  Achiral Molecular Recognition of Substituted Aniline Position Isomers by Crown Ether Type Chiral Stationary Phase.

Authors:  Atsushi Ohnishi; Tohru Shibata; Tatsuya Imase; Satoshi Shinkura; Kanji Nagai
Journal:  Molecules       Date:  2021-01-18       Impact factor: 4.411

5.  Application of Polysaccharide-Based Chiral High-Performance Liquid Chromatography Columns for the Separation of Regio-, E/Z-, and Enantio-Isomeric Mixtures of Allylic Compounds.

Authors:  Takehito Ohji; Atsushi Ohnishi; Masamichi Ogasawara
Journal:  ACS Omega       Date:  2022-02-03

6.  Direct enantiomeric resolution of betaxolol with application to analysis of pharmaceutical products.

Authors:  Mohamed M Hefnawy; Maha A Sultan; Mona M Al-Shehri
Journal:  Anal Chem Insights       Date:  2007-02-06
  6 in total

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