A M Chrobot1, A Szaflarska-Szczepanik, G Drewa. 1. Department of Pediatrics, Gastroenterology and Allergology, Medical University, ul. Ujejskiego 75, 85-168 Bydgoszcz, Poland.
Abstract
INTRODUCTION: The aim of the study was estimation of antioxidant defence state in children with chronic viral hepatitis. MATERIAL AND METHODS: We examined 100 children with chronic viral hepatitis who have serological and molecular markers of HBV or HCV infection. In all patients catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in erythrocytes were assayed. RESULTS: We observed statistically significant decrease of CAT and SOD activities and increase of GSH-Px activity in children with chronic hepatitis B and C. CONCLUSIONS: Our data suggest the possibility of insufficiency of antioxidant barrier in children with chronic viral hepatitis.
INTRODUCTION: The aim of the study was estimation of antioxidant defence state in children with chronic viral hepatitis. MATERIAL AND METHODS: We examined 100 children with chronic viral hepatitis who have serological and molecular markers of HBV or HCV infection. In all patientscatalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in erythrocytes were assayed. RESULTS: We observed statistically significant decrease of CAT and SOD activities and increase of GSH-Px activity in children with chronic hepatitis B and C. CONCLUSIONS: Our data suggest the possibility of insufficiency of antioxidant barrier in children with chronic viral hepatitis.
Authors: Nagwa A Ismail; Sawsan H Okasha; A Dhawan; Azza O Abdel-Rahman; Olfat G Shaker; Nehal A Sadik Journal: Saudi J Gastroenterol Date: 2010 Apr-Jun Impact factor: 2.485