BACKGROUND & AIMS: The impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection upon B vitamins status and antioxidative defense in infected patients was examined. METHODS: Dietary record and blood levels of B vitamins and oxidative stress-associated biomarkers were determined for 195 healthy controls, 132 HBV, and 114 HCV patients. RESULTS: HBV-infected patients had significantly higher levels of total cholesterol, free fatty acids (FFA), and lower ghrelin level (p < 0.05); and HCV-infected patients had significantly higher Ishak inflammation score and lactate dehydrogenase activity (p < 0.05). HBV patients had significantly lower red blood cell (RBC) vitamins B(2) and B(6) levels, and HCV infection significantly decreased vitamins B(2,) B(6) and folate levels in RBC and/or plasma (p < 0.05). Correlation coefficients of RBC vitamin B(2) versus serum FFA in HBV patients, RBC vitamins B(2) and B(6) versus HCV RNA and Ishak inflammation score, and plasma vitamin B(6) vs Ishak inflammation score in HCV patients were <-0.5. HBV-infected patients had significantly higher oxidized glutathione level and lower glutathione peroxidase activity (p < 0.05), but HCV patients had significantly lower superoxide dismutase and catalase activities (p < 0.05). CONCLUSION: HBV or HCV infection enhanced oxidative stress and lowered B vitamins in circulation. In order to avoid other healthy risk, nutrition status should be monitored and limitation or supplementation of certain nutrients might be helpful for HBV- or HCV-infected patients.
BACKGROUND & AIMS: The impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection upon B vitamins status and antioxidative defense in infectedpatients was examined. METHODS: Dietary record and blood levels of B vitamins and oxidative stress-associated biomarkers were determined for 195 healthy controls, 132 HBV, and 114 HCVpatients. RESULTS:HBV-infectedpatients had significantly higher levels of total cholesterol, free fatty acids (FFA), and lower ghrelin level (p < 0.05); and HCV-infectedpatients had significantly higher Ishak inflammation score and lactate dehydrogenase activity (p < 0.05). HBVpatients had significantly lower red blood cell (RBC) vitamins B(2) and B(6) levels, and HCV infection significantly decreased vitamins B(2,) B(6) and folate levels in RBC and/or plasma (p < 0.05). Correlation coefficients of RBC vitamin B(2) versus serum FFA in HBVpatients, RBC vitamins B(2) and B(6) versus HCV RNA and Ishak inflammation score, and plasma vitamin B(6) vs Ishak inflammation score in HCVpatients were <-0.5. HBV-infectedpatients had significantly higher oxidized glutathione level and lower glutathione peroxidase activity (p < 0.05), but HCVpatients had significantly lower superoxide dismutase and catalase activities (p < 0.05). CONCLUSION:HBV or HCV infection enhanced oxidative stress and lowered B vitamins in circulation. In order to avoid other healthy risk, nutrition status should be monitored and limitation or supplementation of certain nutrients might be helpful for HBV- or HCV-infectedpatients.
Authors: Dinesh Talwar; Tara Quasim; Donald C McMillan; John Kinsella; Cathy Williamson; Denis St J O'Reilly Journal: J Chromatogr B Analyt Technol Biomed Life Sci Date: 2003-07-25 Impact factor: 3.205
Authors: E Christina Persson; Lauren M Schwartz; Yikyung Park; Britton Trabert; Albert R Hollenbeck; Barry I Graubard; Neal D Freedman; Katherine A McGlynn Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-01-10 Impact factor: 4.254