Literature DB >> 11206454

3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents.

Y Kashiwada1, J Chiyo, Y Ikeshiro, T Nagao, H Okabe, L M Cosentino, K Fowke, K H Lee.   

Abstract

Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 3-O-(3',3'-Dimethylsuccinyl)-28-O-(2", 2"-dimethvlsuccinyl)-betulin (11) was the most potent anti-HIV compound with an EC5, value of 0.00087 microM and a TI value of 42,400.

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Year:  2001        PMID： 11206454     DOI： 10.1016/s0960-894x(00)00635-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Study of the betulin molecule in a water environment; ab initio and molecular simulation calculations.

Authors:  Miroslav Pospíšil; Petr Kovář; Robert Vácha; Michal Svoboda
Journal:  J Mol Model       Date:  2011-05-03       Impact factor: 1.810

2.  Conjugates of betulin derivatives with AZT as potent anti-HIV agents.

Authors:  Juan Xiong; Yoshiki Kashiwada; Chin-Ho Chen; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee; Yoshihisa Takaishi
Journal:  Bioorg Med Chem       Date:  2010-07-07       Impact factor: 3.641

3.  Enhancing the divergent activities of betulinic acid via neoglycosylation.

Authors:  Randal D Goff; Jon S Thorson
Journal:  Org Lett       Date:  2009-01-15       Impact factor: 6.005

4.  Design, Synthesis and Preliminary Evaluation of the Cytotoxicity and Antibacterial Activity of Novel Triphenylphosphonium Derivatives of Betulin.

Authors:  Mirosława Grymel; Anna Lalik; Alicja Kazek-Kęsik; Marietta Szewczyk; Patrycja Grabiec; Karol Erfurt
Journal:  Molecules       Date:  2022-08-12       Impact factor: 4.927
  4 in total

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