W D Ratnasooriya1, J R Jayakody. 1. Department of Zoology, University of Colombo, Colombo 3, Sri Lanka. dappvr@sltnet.lk
Abstract
AIM: To evaluate the antireproductive effect of paracetamol in male rats. METHODS: Male rats were orally administered daily with 500 mg/kg or 1000 mg/kg of paracetamol for 30 consecutive days. Their sexual behaviour and fertility were evaluated using receptive females. RESULTS: At 2 h after treatment, sexual behaviour was not inhibited but on day 30 both doses of paracetamol caused marked impairment of libido (assessed by % mounting, % intromission and % ejaculation), sexual vigour (number of mounts and intromissions and copulatory efficiency) or sexual performance (intercopulatory interval). In mating experiments, the fertility (in terms of quantal pregnancy, fertility index, implantation index and number of implants) was significantly reduced. All these effects were reversible. The antireproductive effect was not due to a general toxicity but due to an increase in pre-implantation losses resulting from oligozoospermia, impairments of normal and hyper-activated sperm motility, and reduction in the fertilizing potential of spermatozoa. CONCLUSION: Long-term use of high doses of paracetamol may be detrimental to male reproductive competence.
AIM: To evaluate the antireproductive effect of paracetamol in male rats. METHODS: Male rats were orally administered daily with 500 mg/kg or 1000 mg/kg of paracetamol for 30 consecutive days. Their sexual behaviour and fertility were evaluated using receptive females. RESULTS: At 2 h after treatment, sexual behaviour was not inhibited but on day 30 both doses of paracetamol caused marked impairment of libido (assessed by % mounting, % intromission and % ejaculation), sexual vigour (number of mounts and intromissions and copulatory efficiency) or sexual performance (intercopulatory interval). In mating experiments, the fertility (in terms of quantal pregnancy, fertility index, implantation index and number of implants) was significantly reduced. All these effects were reversible. The antireproductive effect was not due to a general toxicity but due to an increase in pre-implantation losses resulting from oligozoospermia, impairments of normal and hyper-activated sperm motility, and reduction in the fertilizing potential of spermatozoa. CONCLUSION: Long-term use of high doses of paracetamol may be detrimental to male reproductive competence.
Authors: Kawthar A Diab; Maha A Fahmy; Emad M Hassan; Zeinab M Hassan; Enayat A Omara; Negm S Abdel-Samie Journal: Mol Biol Rep Date: 2020-01-25 Impact factor: 2.316
Authors: Amelia K Wesselink; Kathryn A Bresnick; Elizabeth E Hatch; Kenneth J Rothman; Ellen M Mikkelsen; Tanran R Wang; Krista F Huybrechts; Lauren A Wise Journal: Am J Epidemiol Date: 2020-11-02 Impact factor: 4.897