Literature DB >> 11199135

Inhibition of neutrophil elastase activity by cinnamic acid derivatives from Cimicifuga racemosa.

B Löser, S O Kruse, M F Melzig, A Nahrstedt.   

Abstract

Caffeic acid, fukinolic acid as well as cimicifugic acids A, B, E and F isolated from the rhizomes of Cimicifuga racemosa (Ranunculaceae) inhibited the activity of neutrophil elastase (EC 3.4.21.37) in a dose-dependent manner. An IC50 of 93 mumol/L was determined for caffeic acid and 0.23 mumol/L for fukinolic acid. Cimicifugic acid A inhibited the enzyme with an IC50 of 2.2 mumol/L, cimicifugic acid B with 11.4 mumol/L, and cimicifugic acid F with 18 mumol/L. Cimicifugic acid E was only a very weak inhibitor.

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Year:  2000        PMID： 11199135     DOI： 10.1055/s-2000-9563

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  5 in total

1.  Analysis of polyphenolic compounds and radical scavenging activity of four American Actaea species.

Authors:  Paiboon Nuntanakorn; Bei Jiang; Hui Yang; Miguel Cervantes-Cervantes; Fredi Kronenberg; Edward J Kennelly
Journal:  Phytochem Anal       Date:  2007 May-Jun       Impact factor: 3.373

2.  Black Cohosh: Insights into its Mechanism(s) of Action.

Authors:  Rachel L Ruhlen; Grace Y Sun; Edward R Sauter
Journal:  Integr Med Insights       Date:  2008-08-27

3.  4-hydroxy-2-nonenal-modified glyceraldehyde-3-phosphate dehydrogenase is degraded by cathepsin G in rat neutrophils.

Authors:  Yukihiro Tsuchiya; Go Okada; Shigeki Kobayashi; Toshiyuki Chikuma; Hiroshi Hojo
Journal:  Oxid Med Cell Longev       Date:  2011-04-10       Impact factor: 6.543

4.  EGCG reverses human neutrophil elastase-induced migration in A549 cells by directly binding to HNE and by regulating α1-AT.

Authors:  Yilixiati Xiaokaiti; Haoming Wu; Ya Chen; Haopeng Yang; Jianhui Duan; Xin Li; Yan Pan; Lu Tie; Liangren Zhang; Xuejun Li
Journal:  Sci Rep       Date:  2015-07-16       Impact factor: 4.379

Review 5.  Benefits of Black Cohosh (Cimicifuga racemosa) for Women Health: An Up-Close and In-Depth Review.

Authors:  Sradhanjali Mohapatra; Ashif Iqubal; Mohammad Javed Ansari; Bisma Jan; Sultan Zahiruddin; Mohd Aamir Mirza; Sayeed Ahmad; Zeenat Iqbal
Journal:  Pharmaceuticals (Basel)       Date:  2022-02-23
  5 in total

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