UNLABELLED: 11C-acetate has been used extensively for the noninvasive assessment of myocardial oxygen consumption and viability with PET. The use of early uptake of acetate by the heart to measure myocardial perfusion has been proposed. This study evaluated the application of 11C-acetate for absolute measurement of myocardial blood flow using a simple compartmental model that does not require blood sampling. METHODS: Eight healthy volunteers and 13 subjects with concentric left ventricular hypertrophy were studied under resting conditions with both 11Cacetate and 15O-water. Myocardial blood flow with 11C-acetate was obtained by fitting the first 3 min of the blood and tissue tracer activity curves to a two-compartment model. Flows obtained were compared with a validated approach using 15O-water. RESULTS: In healthy volunteers, regional myocardial perfusion at rest estimated with 11C-acetate was comparable with values obtained with 15O-water (1.06 +/- 0.25 and 0.96 +/- 0.12 mL/g/min, respectively). Perfusion in subjects with left ventricular hypertrophy was also comparable if the recovery coefficient (FMM) used was corrected for ventricular mass. If a fixed FMM was used, flow was greatly overestimated. FMM could be estimated from left ventricular mass (FMM = 0.46 + 0.002 x mass, r = 0.86, P < 0.0001). CONCLUSION: The results of this study suggest that 11C-acetate can be applied to quantitatively estimate myocardial perfusion under resting conditions using a two-compartment model without the need for blood sampling, provided that an appropriate FMM is chosen. This approach should increase the usefulness of this tracer and obviate administration of a separate tracer to independently measure perfusion.
UNLABELLED: 11C-acetate has been used extensively for the noninvasive assessment of myocardial oxygen consumption and viability with PET. The use of early uptake of acetate by the heart to measure myocardial perfusion has been proposed. This study evaluated the application of 11C-acetate for absolute measurement of myocardial blood flow using a simple compartmental model that does not require blood sampling. METHODS: Eight healthy volunteers and 13 subjects with concentric left ventricular hypertrophy were studied under resting conditions with both 11Cacetate and 15O-water. Myocardial blood flow with 11C-acetate was obtained by fitting the first 3 min of the blood and tissue tracer activity curves to a two-compartment model. Flows obtained were compared with a validated approach using 15O-water. RESULTS: In healthy volunteers, regional myocardial perfusion at rest estimated with 11C-acetate was comparable with values obtained with 15O-water (1.06 +/- 0.25 and 0.96 +/- 0.12 mL/g/min, respectively). Perfusion in subjects with left ventricular hypertrophy was also comparable if the recovery coefficient (FMM) used was corrected for ventricular mass. If a fixed FMM was used, flow was greatly overestimated. FMM could be estimated from left ventricular mass (FMM = 0.46 + 0.002 x mass, r = 0.86, P < 0.0001). CONCLUSION: The results of this study suggest that 11C-acetate can be applied to quantitatively estimate myocardial perfusion under resting conditions using a two-compartment model without the need for blood sampling, provided that an appropriate FMM is chosen. This approach should increase the usefulness of this tracer and obviate administration of a separate tracer to independently measure perfusion.
Authors: Ashley M Groves; Vicky Goh; Sabarinath Rajasekharan; Irfan Kayani; Raymondo Endozo; John C Dickson; Leon J Menezes; Manu Shastry; Said B Habib; Peter J Ell; Brian F Hutton Journal: Eur Radiol Date: 2008-05-09 Impact factor: 5.315
Authors: Nils Henrik Hansson; Lars Tolbod; Hendrik Johannes Harms; Henrik Wiggers; Won Yong Kim; Esben Hansen; Tomas Zaremba; Jørgen Frøkiær; Steen Jakobsen; Jens Sørensen Journal: J Nucl Cardiol Date: 2016-04-19 Impact factor: 5.952
Authors: Hugo W A M de Jong; Luuk J Rijzewijk; Mark Lubberink; Rutger W van der Meer; Hildo J Lamb; Jan W A Smit; Michaëla Diamant; Adriaan A Lammertsma Journal: Eur J Nucl Med Mol Imaging Date: 2009-01-27 Impact factor: 9.236
Authors: Klaes Golman; Jan H Ardenkjaer-Larsen; J Stefan Petersson; Sven Mansson; Ib Leunbach Journal: Proc Natl Acad Sci U S A Date: 2003-08-20 Impact factor: 11.205
Authors: S A J Timmer; M Lubberink; T Germans; M J W Götte; J M ten Berg; F J ten Cate; A C van Rossum; A A Lammertsma; P Knaapen Journal: J Nucl Cardiol Date: 2009-12-29 Impact factor: 5.952