| Literature DB >> 1119420 |
R L Gross, J V Reid, P M Newberne, B Burgess, R Marston, W Hift.
Abstract
Cell-mediated immunity has been studied in patients with 1) megaloblastic anemia of folic acid deficiency, 2)megaloblastic anemia of pregnancy, or 3) iron-deficiency anemia. Using dinitrochlorobenzene skin tests, phytohemagglutinin-stimulated lymphocyte transformation, and rosette inhibition by antilymphocyte globulin, we have shown that cell-mediated immunity is depressed in megaloblastic anemia due to folate deficiency; this depression was reversed by folate treatment. Cell-mediated immunity was not impaired by iron-deficiency anemia. Suggested interactions between iron deficiency and folate metabolism were not clarified by these studies.Entities:
Mesh：
Substances：
Year: 1975 PMID： 1119420 DOI： 10.1093/ajcn/28.3.225
Source DB: PubMed Journal: Am J Clin Nutr ISSN： 0002-9165 Impact factor: 7.045