Literature DB >> 11185406

Genomics and gene therapy. Artificial chromosomes coming to life.

H F Willard1.   

Abstract

One of the biggest obstacles to gene therapy is the delivery of the therapeutic gene to the target tissue so that it is appropriately expressed. In his Perspective, Willard looks at the potential advantages of using a human artificial chromosome to maintain expression of a therapeutic gene and discusses some of the hurdles yet to be overcome before this gene delivery system can be tried out in the clinic.

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Year:  2000        PMID： 11185406     DOI： 10.1126/science.290.5495.1308

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

1.  Neocentromeres and human artificial chromosomes: an unnatural act.

Authors:  H F Willard
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-08       Impact factor: 11.205

2.  Computational and analytical modeling of cationic lipid-DNA complexes.

Authors:  Oded Farago; Niels Grønbech-Jensen
Journal:  Biophys J       Date:  2007-01-26       Impact factor: 4.033

3.  Fluorescence microscopy colocalization of lipid-nucleic acid nanoparticles with wildtype and mutant Rab5-GFP: A platform for investigating early endosomal events.

Authors:  Ramsey N Majzoub; Chia-Ling Chan; Kai K Ewert; Bruno F B Silva; Keng S Liang; Cyrus R Safinya
Journal:  Biochim Biophys Acta       Date:  2015-03-06

4.  Differential rates of local and global homogenization in centromere satellites from Arabidopsis relatives.

Authors:  Sarah E Hall; Song Luo; Anne E Hall; Daphne Preuss
Journal:  Genetics       Date:  2005-06-03       Impact factor: 4.562

5.  Functional complementation of a genetic deficiency with human artificial chromosomes.

Authors:  J E Mejía; A Willmott; E Levy; W C Earnshaw; Z Larin
Journal:  Am J Hum Genet       Date:  2001-07-10       Impact factor: 11.025

6.  Three-dimensional imaging of lipid gene-carriers: membrane charge density controls universal transfection behavior in lamellar cationic liposome-DNA complexes.

Authors:  Alison J Lin; Nelle L Slack; Ayesha Ahmad; Cyril X George; Charles E Samuel; Cyrus R Safinya
Journal:  Biophys J       Date:  2003-05       Impact factor: 4.033

7.  Role of temperature-independent lipoplex-cell membrane interactions in the efficiency boost of multicomponent lipoplexes.

Authors:  C Marchini; D Pozzi; M Montani; C Alfonsi; A Amici; S Candeloro De Sanctis; M A Digman; S Sanchez; E Gratton; H Amenitsch; A Fabbretti; C O Gualerzi; G Caracciolo
Journal:  Cancer Gene Ther       Date:  2011-03-11       Impact factor: 5.987

Review 8.  Genetic modification of preimplantation embryos: toward adequate human research policies.

Authors:  Rebecca Dresser
Journal:  Milbank Q       Date:  2004       Impact factor: 4.911

9.  Centromere satellites from Arabidopsis populations: maintenance of conserved and variable domains.

Authors:  Sarah E Hall; Gregory Kettler; Daphne Preuss
Journal:  Genome Res       Date:  2003-02       Impact factor: 9.043

10.  Uptake and transfection efficiency of PEGylated cationic liposome-DNA complexes with and without RGD-tagging.

Authors:  Ramsey N Majzoub; Chia-Ling Chan; Kai K Ewert; Bruno F B Silva; Keng S Liang; Erica L Jacovetty; Bridget Carragher; Clinton S Potter; Cyrus R Safinya
Journal:  Biomaterials       Date:  2014-03-21       Impact factor: 12.479
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