Literature DB >> 11181956

Molecular diversity of pacemaker ion channels.

U B Kaupp1, R Seifert.   

Abstract

Ionic currents activated by hyperpolarization and regulated by cyclic nucleotides were first discovered more than 20 years ago. Recently the molecular identity of the underlying channels has been unveiled. The structural features of the protein sequences are discussed and related to the mechanisms of activation, selectivity for cyclic nucleotides, and ion permeation. Coverage includes a comparison of the biophysical properties of recombinant and native channels and their significance for the physiological functions of these channels.

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Year:  2001        PMID： 11181956     DOI： 10.1146/annurev.physiol.63.1.235

Source DB:  PubMed          Journal:  Annu Rev Physiol        ISSN： 0066-4278            Impact factor:   19.318


  104 in total

1.  Sequence-function analysis of the K+-selective family of ion channels using a comprehensive alignment and the KcsA channel structure.

Authors:  Robin T Shealy; Anuradha D Murphy; Rampriya Ramarathnam; Eric Jakobsson; Shankar Subramaniam
Journal:  Biophys J       Date:  2003-05       Impact factor: 4.033

2.  Postnatal development of the hyperpolarization-activated excitatory current Ih in mouse hippocampal pyramidal neurons.

Authors:  Dmitry V Vasilyev; Michael E Barish
Journal:  J Neurosci       Date:  2002-10-15       Impact factor: 6.167

3.  Functional expression of the hyperpolarization-activated, non-selective cation current I(f) in immortalized HL-1 cardiomyocytes.

Authors:  Laura Sartiani; Pascal Bochet; Elisabetta Cerbai; Alessandro Mugelli; Rodolphe Fischmeister
Journal:  J Physiol       Date:  2002-11-15       Impact factor: 5.182

4.  Convergent and reciprocal modulation of a leak K+ current and I(h) by an inhalational anaesthetic and neurotransmitters in rat brainstem motoneurones.

Authors:  Jay E Sirois; Carl Lynch; Douglas A Bayliss
Journal:  J Physiol       Date:  2002-06-15       Impact factor: 5.182

5.  Kappa-opioid receptor-mediated enhancement of the hyperpolarization-activated current (I(h)) through mobilization of intracellular calcium in rat nucleus raphe magnus.

Authors:  Zhizhong Z Pan
Journal:  J Physiol       Date:  2003-03-21       Impact factor: 5.182

6.  Ih channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [3H]-noradrenaline release in rat neocortex slices.

Authors:  Maximilian Klar; Rainer Surges; Thomas J Feuerstein
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-03-13       Impact factor: 3.000

7.  The expression and role of hyperpolarization-activated and cyclic nucleotide-gated channels in endocrine anterior pituitary cells.

Authors:  Karla Kretschmannova; Marek Kucka; Arturo E Gonzalez-Iglesias; Stanko S Stojilkovic
Journal:  Mol Endocrinol       Date:  2011-12-01

8.  Modulation of rod photoreceptor output by HCN1 channels is essential for regular mesopic cone vision.

Authors:  Mathias W Seeliger; Arne Brombas; Reto Weiler; Peter Humphries; Gabriel Knop; Naoyuki Tanimoto; Frank Müller
Journal:  Nat Commun       Date:  2011-11-08       Impact factor: 14.919

9.  MATLAB implementation of a dynamic clamp with bandwidth of >125 kHz capable of generating I Na at 37 °C.

Authors:  Chris Clausen; Virginijus Valiunas; Peter R Brink; Ira S Cohen
Journal:  Pflugers Arch       Date:  2012-12-09       Impact factor: 3.657

10.  Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells.

Authors:  Sebastian Wachten; Nanako Masada; Laura-Jo Ayling; Antonio Ciruela; Viacheslav O Nikolaev; Martin J Lohse; Dermot M F Cooper
Journal:  J Cell Sci       Date:  2010-01-01       Impact factor: 5.285
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