| Literature DB >> 11175782 |
M Pravenec1, V Landa, V Zidek, A Musilova, V Kren, L Kazdova, T J Aitman, A M Glazier, A Ibrahimi, N A Abumrad, N Qi, J M Wang, E M St Lezin, T W Kurtz.
Abstract
Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11175782 DOI： 10.1038/84777
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330