Literature DB >> 11170844

Antibody-induced activation of beta1 integrin receptors stimulates cAMP-dependent migration of breast cells on laminin-5.

G E Plopper1, J L Huff, W L Rust, M A Schwartz, V Quaranta.   

Abstract

The beta1 integrin-stimulating antibody TS2/16 induces cAMP-dependent migration of MCF-10A breast cells on the extracellular matrix protein laminin-5. TS2/16 stimulates a rise in intracellular cAMP within 20 min after plating. Pertussis toxin, which inhibits both antibody-induced migration and cAMP accumulation, targets the Galphai3 subunit of heterotrimeric G proteins in these cells, suggesting that Galphai3 may link integrin activation and migration via a cAMP signaling pathway. Copyright 2000 Academic Press.

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Year:  2000        PMID： 11170844     DOI： 10.1006/mcbr.2001.0267

Source DB:  PubMed          Journal:  Mol Cell Biol Res Commun        ISSN： 1522-4724


  8 in total

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4.  Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migration.

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  8 in total

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