Literature DB >> 11170019

Oxidative degradation of pharmaceuticals: theory, mechanisms and inhibition.

S Hovorka1, C Schöneich.   

Abstract

Oxidation is a common pathway for drug degradation in liquid and solid formulations. The present article reviews mechanistic details of autoxidation and chain oxidation processes, as well as the oxidation of selected functional groups commonly affected in drugs.

Mesh：

Substances：

Year:  2001        PMID： 11170019     DOI： 10.1002/1520-6017(200103)90:3<253::aid-jps1>3.0.co;2-w

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  33 in total

Review 1.  Reactive impurities in excipients: profiling, identification and mitigation of drug-excipient incompatibility.

Authors:  Yongmei Wu; Jaquan Levons; Ajit S Narang; Krishnaswamy Raghavan; Venkatramana M Rao
Journal:  AAPS PharmSciTech       Date:  2011-09-27       Impact factor: 3.246

2.  Impact of long-term storage on stability of standard DNA for nucleic acid-based methods.

Authors:  Barbara Röder; Karin Frühwirth; Claus Vogl; Martin Wagner; Peter Rossmanith
Journal:  J Clin Microbiol       Date:  2010-09-01       Impact factor: 5.948

3.  Early prediction of pharmaceutical oxidation pathways by computational chemistry and forced degradation.

Authors:  Darren L Reid; C Jeffrey Calvitt; Mark T Zell; Kenneth G Miller; Carol A Kingsmill
Journal:  Pharm Res       Date:  2004-09       Impact factor: 4.200

4.  Discovery pharmaceutics--challenges and opportunities.

Authors:  Xue-Qing Chen; Melissa D Antman; Christoph Gesenberg; Olafur S Gudmundsson
Journal:  AAPS J       Date:  2006-06-02       Impact factor: 4.009

Review 5.  Stability of protein pharmaceuticals: an update.

Authors:  Mark Cornell Manning; Danny K Chou; Brian M Murphy; Robert W Payne; Derrick S Katayama
Journal:  Pharm Res       Date:  2010-02-09       Impact factor: 4.200

6.  Mechanism of the solution oxidation of rofecoxib under alkaline conditions.

Authors:  Paul A Harmon; Stephen Biffar; Steven M Pitzenberger; Robert A Reed
Journal:  Pharm Res       Date:  2005-09-22       Impact factor: 4.200

7.  Polymeric systems for amorphous Delta9-tetrahydrocannabinol produced by a hot-melt method. Part II: Effect of oxidation mechanisms and chemical interactions on stability.

Authors:  Manish Munjal; Mahmoud A Elsohly; Michael A Repka
Journal:  J Pharm Sci       Date:  2006-11       Impact factor: 3.534

8.  Mechanism of Decarboxylation of Pyruvic Acid in the Presence of Hydrogen Peroxide.

Authors:  Antonio Lopalco; Gautam Dalwadi; Sida Niu; Richard L Schowen; Justin Douglas; Valentino J Stella
Journal:  J Pharm Sci       Date:  2016-01-29       Impact factor: 3.534

9.  A quantitative kinetic study of polysorbate autoxidation: the role of unsaturated fatty acid ester substituents.

Authors:  Jia Yao; Dushyanth K Dokuru; Matthew Noestheden; SungAe S Park; Bruce A Kerwin; Janan Jona; Drazen Ostovic; Darren L Reid
Journal:  Pharm Res       Date:  2009-08-08       Impact factor: 4.200

10.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors:  Douglas B Kell
Journal:  BMC Med Genomics       Date:  2009-01-08       Impact factor: 3.063
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.